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1. (WO2013152418) SYSTEM AND METHOD FOR MULTIPHASIC RELEASE OF GROWTH FACTORS

Pub. No.:    WO/2013/152418    International Application No.:    PCT/CA2012/050738
Publication Date: Fri Oct 18 01:59:59 CEST 2013 International Filing Date: Thu Oct 18 01:59:59 CEST 2012
IPC: A61K 9/00
A61K 38/18
A61K 47/02
A61K 47/30
A61K 47/34
C07K 17/14
C07K 14/475
Applicants: INDUCE BIOLOGICS INC.
Inventors: CLOKIE, Cameron M. L.
PEEL, Sean A. F.
Title: SYSTEM AND METHOD FOR MULTIPHASIC RELEASE OF GROWTH FACTORS
Abstract:
A system for multiphasic delivery of at least one growth factor at a treatment site comprises a delivery vehicle for releasing at least one growth factor in an initial release profile and a carrier for releasing at least one growth factor in a sustained release profile. The initial release profile releases at least one growth factor over a period of hours to days, wherein the growth factor is released in a large amount initially, with the remainder being released in progressively lower amounts. The sustained release profile releases at least one growth factor over a period of days to weeks, wherein the growth factor is released at a generally constant amount over such period. The system of the invention is particularly suited for applications on bioimplants. The invention also comprises methods and kits for multiphasic delivery of at least one growth factor. The invention also comprises calcium sulphate as a carrier for releasing at least one growth factor in both single and multiphasic systems for delivering at least one growth factor at a treatment site.