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1. WO2013152277 - MOENOMYCIN ANALOGS, METHODS OF SYNTHESIS, AND USES THEREOF

Publication Number WO/2013/152277
Publication Date 10.10.2013
International Application No. PCT/US2013/035416
International Filing Date 05.04.2013
IPC
C07F 9/6558 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
6558containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
CPC
C07F 9/65586
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
6558containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
65586at least one of the hetero rings does not contain nitrogen as ring hetero atom
C07H 1/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1Processes for the preparation of sugar derivatives
C07H 13/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
13Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
12by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
C07H 5/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
5Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
04to nitrogen
06Aminosugars
Applicants
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US]/[US]
Inventors
  • KAHNE, Daniel
  • KAHNE, Suzanne, Walker
  • TSUKAMOTO, Hirokazu
Agents
  • BAKER, C., Hunter
Priority Data
61/621,16106.04.2012US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MOENOMYCIN ANALOGS, METHODS OF SYNTHESIS, AND USES THEREOF
(FR) ANALOGUES DE LA MOÉNOMYCINE, PROCÉDÉS DE SYNTHÈSE, ET LEURS UTILISATIONS
Abstract
(EN)
The present invention provides compounds of Formula (I); or a pharmaceutically acceptable form thereof; wherein R 1,R2,R3,R6,R7,R12,Ra, and Rb are as defined herein, and G is a group of Formula (a), (b), or (c): Formula (II), wherein X1; X2, X3, X4, X5, X6, X7, Y, RC, Rd, Rz, a, d, e, x, n, and m are as defined herein. The present invention further provides pharmaceutical compositions comprising a compound of Formula (I), kits comprising such compositions, methods of use and treatment, and preparative methods.
(FR)
La présente invention concerne des composés de Formule (I); ou leur forme pharmaceutiquement acceptable; dans laquelle les R1, R2, R3, R6, R7, R12, Ra, et Rb sont tels que définis dans la description, et G représente un groupe de Formule (a), (b), ou (c) : et de Formule (II), dans laquelle X1, X2, X3, X4, X5, X6, X7, Y, RC, Rd, Rz, a, d, e, x, n, et m sont tels que définis dans la description. La présente invention concerne en outre des compositions pharmaceutiques comprenant un composé de Formule (I), des kits comprenant de telles compositions, des méthodes d'utilisation et de traitement, et des procédés de préparation.
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