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1. WO2013150072 - DERIVATIVES OF 1-(2-HALO-BIPHENYL-4-YL)- ALKANECARBOXYLIC ACIDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

Publication Number WO/2013/150072
Publication Date 10.10.2013
International Application No. PCT/EP2013/057025
International Filing Date 03.04.2013
IPC
C07C 69/743 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
74Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
743of acids with a three-membered ring and with unsaturation outside the ring
C07C 233/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
01having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
16having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
17with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
18having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
C07C 233/33 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
01having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
30having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
33with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
CPC
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
C07C 233/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
01having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
16having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
17with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
18having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
C07C 233/36
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
01having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
34having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
35with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
36having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
C07C 233/62
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
57having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
62having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
C07C 2601/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
02with a three-membered ring
C07C 61/40
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
61Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
16Unsaturated compounds
40containing halogen
Applicants
  • CHIESI FARMACEUTICI S.P.A. [IT]/[IT]
Inventors
  • IMBIMBO, Bruno Pietro
  • RAVEGLIA, Luca
Agents
  • MINOJA, Fabrizio
Priority Data
12163074.304.04.2012EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DERIVATIVES OF 1-(2-HALO-BIPHENYL-4-YL)- ALKANECARBOXYLIC ACIDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
(FR) DÉRIVÉS D'ACIDES 1-(2-HALO-BIPHÉNYL-4-YL)ALCANECARBOXYLIQUES POUR LE TRAITEMENT DE MALADIES NEURODÉGÉNÉRATIVES
Abstract
(EN)
The present invention concerns pro-drugs of 1-(2-halo-biphenyl-4-yl) alkanecarboxylic acids, pharmaceutical compositions thereof, a process for their preparation and their use for preventing and/or treating neurodegenerative diseases, improving cognitive function and treating cognitive impairment.
(FR)
La présente invention concerne des promédicaments d'acides 1-(2-halo-biphényl-4-yl)alcanecarboxyliques, des compositions pharmaceutiques à base de ceux-ci, un procédé pour leur préparation et leur utilisation pour la prévention et/ou le traitement de maladies neurodégénératives, l'amélioration de la fonction cognitive et le traitement d'un trouble cognitif.
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