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1. WO2013150002 - METHODS AND KITS FOR DETERMINING IF A SUBJECT IS PREDISPOSED TO FAST PROGRESSION OF LIVER FIBROSIS

Publication Number WO/2013/150002
Publication Date 10.10.2013
International Application No. PCT/EP2013/056895
International Filing Date 02.04.2013
IPC
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
C12Q 2600/118
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
118Prognosis of disease development
C12Q 2600/156
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
156Polymorphic or mutational markers
Applicants
  • INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) [FR]/[FR]
  • CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS [CH]/[CH]
Inventors
  • ABEL, Laurent
  • BOCHUD, Pierre-Yves
Agents
  • HIRSCH, Denise
Priority Data
12305399.303.04.2012EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND KITS FOR DETERMINING IF A SUBJECT IS PREDISPOSED TO FAST PROGRESSION OF LIVER FIBROSIS
(FR) PROCÉDÉS ET TROUSSES POUR LA DÉTERMINATION DE SAVOIR SI UN SUJET PRÉSENTE UNE PRÉDISPOSITION VIS-À-VIS D'UNE PROGRESSION RAPIDE DE LA FIBROSE HÉPATIQUE
Abstract
(EN)
The present invention thus relates to a method of determining if a subject is predisposed to fast progression of liver fibrosis, the method comprising testing for said subject the genotype of at least one single nucleotide polymorphism selected from the group consisting of rs16851720, rs4374383 and rs9380516 or any single nucleotide polymorphism in linkage disequilibrium with rs16851720, rs4374383 or rs9380516.
(FR)
La présente invention concerne un procédé de détermination de savoir si un sujet présente une prédisposition vis-à-vis de la progression rapide de la fibrose hépatique, le procédé comprenant le test, pour ledit sujet, du génotype d'au moins un polymorphisme de nucléotide unique choisi dans le groupe consistant en rs16851720, rs4374383 et rs9380516 ou l'un quelconque des polymorphismes de nucléotide unique en déséquilibre de liaison avec rs16851720, rs4374383 ou rs9380516.
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