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1. WO2013149935 - HYPERPOLARIZED AMINO ACIDS

Publication Number WO/2013/149935
Publication Date 10.10.2013
International Application No. PCT/EP2013/056696
International Filing Date 28.03.2013
IPC
A61K 49/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
08characterised by the carrier
10Organic compounds
CPC
A61K 49/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
08characterised by the carrier
10Organic compounds
C07C 231/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
231Preparation of carboxylic acid amides
12by reactions not involving the formation of carboxamide groups
Applicants
  • BRACCO IMAGING SPA [IT]/[IT]
Inventors
  • KARLSSON, Magnus
  • LERCHE, Mathilde, H.
  • JENSEN, Pernille, Rose
Agents
  • RAVIZZA, Claudio
Priority Data
12162792.102.04.2012EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HYPERPOLARIZED AMINO ACIDS
(FR) ACIDES AMINÉS HYPERPOLARISÉS
Abstract
(EN)
Method for manufacturing a hyperpolarized amino acid, in particular glutamine, which substantially limits the formation of by-products, with respect to conventional aqueous preparations of sodium hydroxide with amino acids. The amino acid is in particular admixed with the hydroxide in the substantial absence of water and the dry mixture is dissolved in an anhydrous solvent in the presence of a polarizing agent. The obtained mixture is then subjected to a DNP process and can be used in metabolic MR imaging.
(FR)
L'invention concerne un procédé de fabrication d'un acide aminé hyperpolarisé, en particulier la glutamine, qui limite sensiblement la formation de sous-produits, par rapport à des préparations aqueuses classiques d'hydroxyde de sodium avec des acides aminés. L'acide aminé est en particulier incorporé avec l'hydroxyde en l'absence substantielle d'eau et le mélange sec est dissous dans un solvant anhydre en présence d'un agent de polarisation. Le mélange obtenu est ensuite soumis à un procédé de polarisation nucléaire dynamique (DNP) et peut être utilisé dans l'imagerie par résonance magnétique (MR) métabolique.
Also published as
Latest bibliographic data on file with the International Bureau