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1. (WO2013149162) P53 COOPERATION WITH DNA METHYLATION AND SUICIDAL INTERFERON RESPONSE TO CONTROL SILENCING OF REPEATS AND NCRNAS

Pub. No.:    WO/2013/149162    International Application No.:    PCT/US2013/034632
Publication Date: Fri Oct 04 01:59:59 CEST 2013 International Filing Date: Sat Mar 30 00:59:59 CET 2013
IPC: C12Q 1/68
Applicants: HEALTH RESEARCH, INC.
Inventors: GUDKOV, Andrei
LEONOVA, Yekaterina
Title: P53 COOPERATION WITH DNA METHYLATION AND SUICIDAL INTERFERON RESPONSE TO CONTROL SILENCING OF REPEATS AND NCRNAS
Abstract:
Provided is a disclosure of methods involving determining RNA transcripts transcribed from repeats of polynucleotide sequences, the transcription of which are normally repressed by a combination of functional p53 and DNA methylation, and methods of detecting interferon, and determining constitutive activation of an interferon type I response. The methods permit identification of cancerous or precancerous cells, can identify non-functional p53, and provide therapeutic and prophylactic approaches for cancer.