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1. (WO2013149129) PURIFICATION OF GLUCOSE CONCENTRATION SIGNAL IN AN IMPLANTABLE FLUORESCENCE BASED GLUCOSE SENSOR

Pub. No.:    WO/2013/149129    International Application No.:    PCT/US2013/034575
Publication Date: Fri Oct 04 01:59:59 CEST 2013 International Filing Date: Sat Mar 30 00:59:59 CET 2013
IPC: A61B 5/00
A61B 5/05
Applicants: SENSEONICS, INCORPORATED
Inventors: COLVIN, Arthur, E.
WANG, Xiaolin
MDINGI, Colleen
DEHENNIS, Andrew
Title: PURIFICATION OF GLUCOSE CONCENTRATION SIGNAL IN AN IMPLANTABLE FLUORESCENCE BASED GLUCOSE SENSOR
Abstract:
Methods, sensors, and systems for determining a concentration of glucose in a medium of a living animal are disclosed. Determining the glucose concentration may involve emitting excitation light from a light source to indicator molecules, generating a raw signal indicative of the amount of light received by a photodetector, purifying and normalizing the raw signal, and converting the normalized signal to a glucose concentration. The purification may involve removing noise (e.g., offset and/or distortion) from the raw signal. The purification and normalization may involve tracking the cumulative emission time that the light source has emitted the excitation light and tracking the implant time that has elapsed since the optical sensor was implanted. The purification and normalization may involve measuring the temperature of the sensor. The purification, normalization, and conversion may involve using parameters determined during manufacturing, in vitro testing, and/or in vivo testing.