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1. (WO2013149124) SMALL MOLECULE INHIBITORS OF MCL-1 AND USES THEREOF

Pub. No.:    WO/2013/149124    International Application No.:    PCT/US2013/034565
Publication Date: Fri Oct 04 01:59:59 CEST 2013 International Filing Date: Sat Mar 30 00:59:59 CET 2013
IPC: C07D 407/14
C07D 413/14
A61K 31/496
A61K 31/5377
A61P 35/00
Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
NIKOLOVSKA-COLESKA, Zaneta
BAJWA, Naval
LIAO, Chenzhong
MIAO, Lei
Inventors: NIKOLOVSKA-COLESKA, Zaneta
BAJWA, Naval
LIAO, Chenzhong
MIAO, Lei
Title: SMALL MOLECULE INHIBITORS OF MCL-1 AND USES THEREOF
Abstract:
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a [(1-Piperazinyl)-4-pyridinylmethyl]-Naphtho[1,2-b]furan structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.