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1. (WO2013149124) SMALL MOLECULE INHIBITORS OF MCL-1 AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/149124    International Application No.:    PCT/US2013/034565
Publication Date: 03.10.2013 International Filing Date: 29.03.2013
IPC:
C07D 407/14 (2006.01), C07D 413/14 (2006.01), A61K 31/496 (2006.01), A61K 31/5377 (2006.01), A61P 35/00 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN [US/US]; 1600 Huron Parkway Second Floor Ann Arbor, Michigan 48109-2590 (US).
NIKOLOVSKA-COLESKA, Zaneta [MK/US]; (US) (US only).
BAJWA, Naval [IN/US]; (US) (US only).
LIAO, Chenzhong [CN/CN]; (CN) (US only).
MIAO, Lei [CN/US]; (US) (US only)
Inventors: NIKOLOVSKA-COLESKA, Zaneta; (US).
BAJWA, Naval; (US).
LIAO, Chenzhong; (CN).
MIAO, Lei; (US)
Agent: GOETZ, Robert; Casimir Jones SC 2275 Deming Way Suite 310 Middleton, Wisconsin 53562 (US)
Priority Data:
61/617,473 29.03.2012 US
Title (EN) SMALL MOLECULE INHIBITORS OF MCL-1 AND USES THEREOF
(FR) INHIBITEURS DE MCL-1 À PETITE MOLÉCULE ET UTILISATIONS DE CEUX-CI
Abstract: front page image
(EN)This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a [(1-Piperazinyl)-4-pyridinylmethyl]-Naphtho[1,2-b]furan structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.
(FR)La présente invention concerne le domaine de la chimie médicinale. En particulier, l'invention concerne une nouvelle classe de petites molécules ayant une structure de [(1-pipérazinyl)-4-pyridinylméthyl]-naphto[1,2-b]furane qui fonctionnent en tant qu'inhibiteurs de protéine Mcl-1, et leur utilisation en tant qu'agents thérapeutiques pour le traitement du cancer et d'autres maladies.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)