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1. (WO2013149010) ENHANCED ANTIMICROBIAL LYTIC ACTIVITY OF A CHIMERIC PLY187 ENDOLYSIN
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/149010 International Application No.: PCT/US2013/034358
Publication Date: 03.10.2013 International Filing Date: 28.03.2013
IPC:
C07K 19/00 (2006.01) ,C07K 14/31 (2006.01) ,C12N 15/62 (2006.01) ,C12N 15/63 (2006.01) ,A61K 38/16 (2006.01) ,A61P 31/04 (2006.01)
Applicants: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE[US/US]; Washington, DC 20250, US
Inventors: DONOVAN, David, M.; US
MAO, Jinzhe; US
Agent: GOLDBERG, Joshua, B.; Nath, Goldberg & Meyer 112 S. West Street Alexandria, VA 22314, US
Priority Data:
13/432,75828.03.2012US
Title (EN) ENHANCED ANTIMICROBIAL LYTIC ACTIVITY OF A CHIMERIC PLY187 ENDOLYSIN
(FR) ACTIVITÉ LYTIQUE ANTIMICROBIENNE AMÉLIORÉE D'UNE ENDOLYSINE CHIMÈRE PLY187
Abstract: front page image
(EN) Peptidoglycan hydrolases are an effective new source of antimicrobials. A chimeric fusion protein of the Ply187 endopeptidase domain and LysK SH3b cell wall binding domain is a potent agent against Staphylococcus aureus in three functional assays.
(FR) L'invention concerne des peptidoglycane hydrolases qui constituent une nouvelle source efficace d'antimicrobiens. Une protéine de fusion chimère du domaine de l'endopeptidase Ply187 et du domaine de liaison de la paroi cellulaire LysK SH3b est un puissant agent contre Staphylococcus aureus dans trois essais fonctionnels.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)