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1. (WO2013148966) TRANSMUCOSAL DELIVERY OF ENGINEERED POLYPEPTIDES

Pub. No.:    WO/2013/148966    International Application No.:    PCT/US2013/034300
Publication Date: Fri Oct 04 01:59:59 CEST 2013 International Filing Date: Fri Mar 29 00:59:59 CET 2013
IPC: A61K 38/16
A61K 38/17
A61P 17/00
Applicants: AMYLIN PHARMACEUTICALS, LLC
ASTRAZENECA PHARMACEUTICALS LP
REN, Steven, Shijun
JIN, Li
Inventors: REN, Steven, Shijun
JIN, Li
Title: TRANSMUCOSAL DELIVERY OF ENGINEERED POLYPEPTIDES
Abstract:
Formulations are provided that comprise compounds having inter alia good duration of action, high potency and/or convenient dosing regimens, and a permeation enhancer for transmucosal administration. The compounds are engineered polypeptides which incorporate an albumin binding domain in combination with one or more biologically active polypeptides. The pharmaceutical compositions provided are suitable for methods of treatment for diseases and disorders including obesity and overweight, diabetes, dyslipidemia, hyperlipidemia, Alzheimer's disease, fatty liver disease, short bowel syndrome, Parkinson's disease, cardiovascular disease, and other and disorders of the central nervous system.