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1. (WO2013148891) PARENTERAL FORMULATIONS FOR ADMINISTERING MACROLIDE ANTIBIOTICS

Pub. No.:    WO/2013/148891    International Application No.:    PCT/US2013/034179
Publication Date: Fri Oct 04 01:59:59 CEST 2013 International Filing Date: Thu Mar 28 00:59:59 CET 2013
IPC: A61K 31/7048
Applicants: CEMPRA PHARMACEUTICALS, INC.
Inventors: PEREIRA, David E.
WU, Sara
FERNANDES, Prabhavathi
Title: PARENTERAL FORMULATIONS FOR ADMINISTERING MACROLIDE ANTIBIOTICS
Abstract:
Pharmaceutical compositions adapted for the parenteral administration, including intravenous administration, of triazole containing macrolide antibiotics, and methods or their use in the treatment of bacterial, protozoal, and other infections are described herein. Also described herein are solid, solution, and liquid formulations for such other therapeutic compounds that are characterized by low solubility and/or low basicity. It has been surprisingly discovered that the formulations described herein that include of one or more lactic acids, one or more amino acids, or combinations thereof, including any pharmaceutically acceptable salts of the foregoing, are useful for the parenteral delivery of such low solubility and/or low basicity therapeutic compounds.