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1. (WO2013148791) NOVEL ALKYLATED IMINO SUGARS EXHIBITING GLUCOSIDASE INHIBITION AND THEIR METHOD OF USE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/148791 International Application No.: PCT/US2013/034033
Publication Date: 03.10.2013 International Filing Date: 27.03.2013
IPC:
A61K 31/445 (2006.01)
Applicants: INSTITUTE FOR HEPATITIS AND VIRUS RESEARCH[US/US]; The Pennsylvania Biotechnology Center 3805 Old Easton Road Doylestown, PA 18902, US
Inventors: DU, Yanming; US
XU, Xiaodong; US
YE, Hong; US
CHANG, Jinhong; US
BLOCK, Timothy, M.; US
Agent: ACETO, Joseph F.; Attorney at Law 1617 Newark Road Kennett Square, PA 19348, US
Priority Data:
61/616,75328.03.2012US
Title (EN) NOVEL ALKYLATED IMINO SUGARS EXHIBITING GLUCOSIDASE INHIBITION AND THEIR METHOD OF USE
(FR) NOUVEAU IMINO SUCRES ALKYLÉS PRÉSENTANT UNE INHIBITION DE LA GLUCOSIDASE ET LEUR PROCÉDÉ D'UTILISATION
Abstract:
(EN) Pharmaceutical compositions of the invention comprise alkylated imino sugars derivatives having a disease-modifying action in the treatment of diseases associated with glucosidase activity that include viral hemorrhagic fevers, and any other diseases involving glucosidase activity. The present invention also relates to a method for treating or preventing diseases that involve infection with viral hemorrhagic fever (VHFs) viruses, including, for example, infection with arenaviruses, filoviruses, bunyaviruses, and flaviviruses, said method comprising administering to a subject an effective amount of a compound or composition according to the present invention.
(FR) L'invention concerne des compositions pharmaceutiques comprenant des dérivés de imino sucres alkylés ayant une action de modification de maladie dans le traitement de maladies associées à l'activité glucosidase qui comprennent des fièvres hémorragiques virales et toutes autres maladies mettant en jeu l'activité glucosidase. La présente invention concerne également une méthode de traitement ou de prévention de maladies qui mettent en jeu l'infection par des virus de la fièvre hémorragique virale (VHF) comprenant, par exemple, une infection par des arénavirus, des filovirus, des bunyavirus et des flavivirus, ladite méthode comprenant l'administration à un sujet d'une quantité efficace d'un composé ou d'une composition selon la présente invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)