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1. (WO2013148710) EFFICIENT SYNTHESIS OF ETHYLENEDICYSTEINE-SUGAR CONJUGATES FOR IMAGING AND THERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/148710    International Application No.:    PCT/US2013/033919
Publication Date: 03.10.2013 International Filing Date: 26.03.2013
IPC:
A61K 49/06 (2006.01), A61K 31/425 (2006.01), A61K 31/70 (2006.01), C07D 277/06 (2006.01), C07D 277/04 (2006.01)
Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM [US/US]; 201 W. 7th Street Austin, TX 78701 (US)
Inventors: YANG, David, J.; (US).
YU, Dong-Fang; (US)
Agent: BYRD, Marshall, P.; Parker Highlander PLLC 1120 S. Capital of Texas Highway Building One, Suite 200 Austin, TX 78746 (US)
Priority Data:
61/615,684 26.03.2012 US
Title (EN) EFFICIENT SYNTHESIS OF ETHYLENEDICYSTEINE-SUGAR CONJUGATES FOR IMAGING AND THERAPY
(FR) SYNTHÈSE EFFICACE DE CONJUGUÉS ÉTHYLÈNEDICYSTÉINE-SUCRE POUR DES APPLICATIONS D'IMAGERIE ET DE THÉRAPIE
Abstract: front page image
(EN)Novel methods of synthesis of ethylenedicysteine-sugar conjugates and therapeutic and diagnostic applications of such conjugates are disclosed. Methods of synthesizing these conjugates in high purity are also presented as using starting materials such as thiazolidine carboxylic acid. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these conjugates prepared herein, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
(FR)La présente invention concerne de nouveaux procédés de synthèse de conjugués éthylènedicystéine-sucre et des applications thérapeutiques et diagnostiques de tels conjugués. L'invention concerne également des procédés permettant de synthétiser lesdits conjugués à une pureté élevée, procédés qui font appel à des matières premières telles que l'acide thiazolidine carboxylique. L'invention concerne aussi des méthodes d'imagerie, de traitement et de diagnostic de maladies chez un sujet au moyen des conjugués ci-décrits, telles que des méthodes d'imagerie d'une tumeur chez un sujet et des méthodes de diagnostic de l'ischémie myocardique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)