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Machine translation
1. (WO2013148550) ASYMMETRIC SYNTHESIS FOR PREPARING FLUOROLEUCINE ALKYL ESTERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/148550    International Application No.:    PCT/US2013/033658
Publication Date: 03.10.2013 International Filing Date: 25.03.2013
IPC:
C07C 17/00 (2006.01), C07C 229/02 (2006.01)
Applicants: MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 (US).
HUMPHREY, Guy [US/US]; (US) (US only).
CHUNG, Cheol, K. [KR/US]; (US) (US only).
RIVERA, Nelo, R. [US/US]; (US) (US only).
BELYK, Kevin, M. [US/US]; (US) (US only)
Inventors: HUMPHREY, Guy; (US).
CHUNG, Cheol, K.; (US).
RIVERA, Nelo, R.; (US).
BELYK, Kevin, M.; (US)
Common
Representative:
MERCK SHARP & DOHME CORP.; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 (US)
Priority Data:
61/617,803 30.03.2012 US
Title (EN) ASYMMETRIC SYNTHESIS FOR PREPARING FLUOROLEUCINE ALKYL ESTERS
(FR) SYNTHÈSE ASYMÉTRIQUE POUR PRÉPARER DES ESTERS D'ALKYLE DE FLUOROLEUCINE
Abstract: front page image
(EN)The instant invention describes a novel asymmetric synthesis of fluoroleucine alkyl esters which utilizes allylation of a glycine derivative containing an imine moiety in the presence of a phase transfer catalyst and a solid additive, followed by fluorination of the alpha-allyl product so obtained, with a fluorinating agent such as Olah's reagent.
(FR)L'invention concerne une nouvelle synthèse asymétrique d'esters d'alkyle de fluoroleucine qui utilise l'allylation d'un dérivé de glycine contenant une fraction imine en présence d'un catalyseur de transfert de phase et d'un additif solide, suivie d'une fluoration du produit alpha-allyle ainsi obtenu au moyen d'un agent de fluoration tel qu'un réactif de Olah.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)