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1. (WO2013148537) SUBSTITUTED SPIROBICYCLIC COMPOUNDS AND METHODS OF USE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/148537 International Application No.: PCT/US2013/033633
Publication Date: 03.10.2013 International Filing Date: 25.03.2013
IPC:
C07D 209/00 (2006.01) ,C07D 209/54 (2006.01) ,C07D 221/20 (2006.01) ,C07D 401/00 (2006.01) ,C07D 513/02 (2006.01) ,C07D 515/02 (2006.01)
Applicants: XI, Ning[US/US]; US
Inventors: XI, Ning; US
LI, Minxiong; CN
ZHOU, Xuan; CN
WU, Yanjun; CN
Agent: XI, Ning; 107 S Via El Toro Newbury Park, CA 91320, US
Priority Data:
61/617,62629.03.2012US
Title (EN) SUBSTITUTED SPIROBICYCLIC COMPOUNDS AND METHODS OF USE
(FR) COMPOSÉS SPIROBICYCLIQUES SUBSTITUÉS ET MÉTHODES D'UTILISATION
Abstract:
(EN) The present invention provides spirobicyclic compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.
(FR) La présente invention concerne des composés spirobicycliques et leurs sels et formulations pharmaceutiquement acceptables utiles dans la modulation de l'activité de la protéine tyrosine kinase, et la modulation d'activités cellulaires telles que la prolifération, la différentiation, l'apoptose, la migration et l'invasion. L'invention concerne également des compositions pharmaceutiquement acceptables comprenant de tels composés et des méthodes d'utilisation dans le traitement des troubles hyperproliferatifs chez les mammifères, en particulier chez l'homme.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)