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1. (WO2013148478) THROMBIN INHIBITORS

Pub. No.:    WO/2013/148478    International Application No.:    PCT/US2013/033399
Publication Date: Fri Oct 04 01:59:59 CEST 2013 International Filing Date: Sat Mar 23 00:59:59 CET 2013
IPC: A61K 31/497
Applicants: MERCK SHARP & DOHME CORP.
BLIZZARD, Timothy Allen
BIFTU, Tesfaye
Inventors: BLIZZARD, Timothy Allen
BIFTU, Tesfaye
Title: THROMBIN INHIBITORS
Abstract:
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: (I) or a pharmaceutically acceptable salt thereof, wherein Q is CH2, NR4, O, S, S(O) or S(O2), wherein R4 is H, C1-6 alkyl, aryl, or C3-8 cycloalkyl; R1 is a heterocycle or -(CR5R6)1-2NH2, wherein R5 and R6, each time in which they occur, are independently H, C1-6 alkyl, -CH2F,-CHF2, CF3 or -CH2OH; R2 is OH, NH2 or NHSO2CH3; and R3 is C1-6 alkyl.