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1. WO2013148400 - METHODS AND COMPOSITION FOR SEQUENCING MODIFIED NUCLEIC ACIDS

Publication Number WO/2013/148400
Publication Date 03.10.2013
International Application No. PCT/US2013/032816
International Filing Date 18.03.2013
IPC
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
G01N 33/48 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
CPC
C12Q 1/6827
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6813Hybridisation assays
6827for detection of mutation or polymorphism
C12Q 1/6869
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6869Methods for sequencing
Y02A 90/10
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
90Technologies having an indirect contribution to adaptation to climate change
10Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Applicants
  • PACIFIC BIOSCIENCES OF CALIFORNIA, INC. [US]/[US]
Inventors
  • KORLACH, Jonas
  • TURNER, Stephen
  • CLARK, Tyson, A.
Agents
  • MANN, Jeffry, S.
Priority Data
61/617,99930.03.2012US
61/721,20601.11.2012US
61/721,33901.11.2012US
61/789,35415.03.2013US
61/799,23715.03.2013US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND COMPOSITION FOR SEQUENCING MODIFIED NUCLEIC ACIDS
(FR) PROCÉDÉS ET COMPOSITION PERMETTANT LE SÉQUENÇAGE D'ACIDES NUCLÉIQUES MODIFIÉS
Abstract
(EN)
Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, a basic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.
(FR)
Des procédés, des compositions et des systèmes sont prévus pour la caractérisation d'acides nucléiques modifiés. Dans certains modes de réalisation préférés, l'invention concerne des procédés de séquençage de molécule unique pour l'identification des nucléotides modifiés dans les séquences d'acide nucléique. Les modifications détectables grâce aux procédés de l'invention concernent les bases chimiquement modifiées, les bases modifiées par voie enzymatique, les sites de base a, les bases non naturelles, les structures secondaires, et les agents liés à un acide nucléique de matrice.
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