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1. (WO2013148372) METHODS FOR AMELIORATION OF AUTOIMMUNE DISEASE USING STEM CELLS TRANSDUCED WITH T CELL RECEPTORS FROM IL-10 SECRETING T CELLS

Pub. No.:    WO/2013/148372    International Application No.:    PCT/US2013/032660
Publication Date: Fri Oct 04 01:59:59 CEST 2013 International Filing Date: Sat Mar 16 00:59:59 CET 2013
IPC: A61K 38/16
A61K 38/10
A61K 38/08
A61K 38/20
A61P 37/00
Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventors: STROMINGER, Jack L.
NG, Sze-Ling
Title: METHODS FOR AMELIORATION OF AUTOIMMUNE DISEASE USING STEM CELLS TRANSDUCED WITH T CELL RECEPTORS FROM IL-10 SECRETING T CELLS
Abstract:
Methods, cells and vectors are provided for treating a subject for an autoimmune disease using stem cells transduced with genes encoding T cell receptors from IL-10 secreting regulatory T cells. The IL-10 secreting regulatory T cells are obtained from a donor of stem cells, the donor having been immunized with peptidic compositions used in the treatment of the autoimmune disease.