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1. (WO2013148332) NUTRITIVE FRAGMENTS AND PROTEINS WITH LOW OR NO PHENYLALANINE AND METHODS

Pub. No.:    WO/2013/148332    International Application No.:    PCT/US2013/032232
Publication Date: Fri Oct 04 01:59:59 CEST 2013 International Filing Date: Sat Mar 16 00:59:59 CET 2013
IPC: C07K 14/435
A23J 3/04
Applicants: PRONUTRIA, INC.
Inventors: BERRY, David, Arthur
BOGHIGIAN, Brett, Adam
SILVER, Nathaniel, W.
VON MALTZAHN, Geoffrey
CHILLAKURU, Rajeev
HAMILL, Michael J.
Title: NUTRITIVE FRAGMENTS AND PROTEINS WITH LOW OR NO PHENYLALANINE AND METHODS
Abstract:
Nutritive proteins comprising no phenylalanine (Phe) are provided. In some embodiments the nutritive proteins comprise at least one of a level of a) a ratio of branch chain amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of branch chain amino acid residues to total amino acid residues present in a benchmark protein; b) a ratio of leucine residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of leucine residues to total amino acid residues present in a benchmark protein; and c) a ratio of essential amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of essential amino acid residues to total amino acid residues present a benchmark protein. Also provided are nucleic acids encoding the proteins, recombinant microorganisms that make the proteins, methods of making the proteins using recombinant microorganisms, compositions that comprise the proteins, and methods of using the proteins, among other things. The compositions are useful, for example, to provide protein in the diet of subjects with a disorder characterized by accumulation of Phe in the body.