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1. (WO2013148302) DELIVERY OF PACKAGED RNA TO MAMMALIAN CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/148302    International Application No.:    PCT/US2013/031876
Publication Date: 03.10.2013 International Filing Date: 15.03.2013
IPC:
C12N 7/00 (2006.01), C12N 15/86 (2006.01)
Applicants: THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; Office of Technology Transfer, National Institutes of Health 6011 Executive Boulevard Suite 325, MSC 7660 Bethesda, MD 20892-7660 (US)
Inventors: KACZMARCZYK, Stanislaw, J.; (US).
CHATTERJEE, Deb, K.; (US)
Agent: CALDWELL, John, W.; Baker & Hostetler LLP Cira Centre, 12th Floor 2929 Arch Street Philadelphia, PA 19104-2891 (US)
Priority Data:
61/615,687 26.03.2012 US
Title (EN) DELIVERY OF PACKAGED RNA TO MAMMALIAN CELLS
(FR) ADMINISTRATION D'ARN ENCAPSULÉ À DES CELLULES DE MAMMIFÈRES
Abstract: front page image
(EN)Described herein are compositions relating to alphavirus-based virus-like particles (VLPs) and methods for making and using the described VLPs. The described compositions include VLPs and vectors and cells used to produce the VLPs. Also included are related methods to produce the VLPs, to transduce cells using the VLPs, and to produce a protein or polynucleotide of interest in a target cell using the VLPs. Also described are alphavirus-based replicons that allow for expression of proteins or polynucleotides of interest in a target cell without a cytopathic effect.
(FR)Les compositions ci-décrites concernent des particules viroïdes à base d'alphavirus (VLP) et des procédés pour les produire et les utiliser. Les compositions décrites comprennent des VLP et les vecteurs et cellules utilisés pour les produire. Des procédés de production des VLP, pour transduire des cellules à l'aide desdites VLP, et pour produire une protéine ou un polynucléotide d'intérêt dans une cellule cible à l'aide des VLP sont également décrits ainsi que de réplicons à base d'alphavirus qui permettent l'expression de protéines ou de polynucléotides d'intérêt dans une cellule cible sans effet cytopathique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)