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1. (WO2013148248) PROTEASE-REGULATED ANTIBODIES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/148248    International Application No.:    PCT/US2013/031363
Publication Date: 03.10.2013 International Filing Date: 14.03.2013
IPC:
A61K 38/00 (2006.01), A61K 39/395 (2006.01), A61P 7/00 (2006.01), C07K 14/745 (2006.01), C07K 16/00 (2006.01)
Applicants: BAYER HEALTHCARE LLC [US/US]; 800 Dwight Way Berkeley, California 94710 (US)
Inventors: WANG, Zhuozhi; (US).
WINTER, Ruth; (US).
MURPHY, John; (US)
Agent: HEMMENDINGER, Lisa M.; Banner & Witcoff, Ltd. 1100 13th Street, N.W. Suite 1200 Washington, District of Columbia 20005-4051 (US)
Priority Data:
61/617,837 30.03.2012 US
Title (EN) PROTEASE-REGULATED ANTIBODIES
(FR) ANTICORPS RÉGULÉS PAR LES PROTÉASES
Abstract: front page image
(EN)This disclosure provides protease-regulated antibodies which specifically bind to tissue factor pathway inhibitor (TFPI). The antibodies are useful for treating bleeding disorders such as hemophilia.
(FR)Cette invention concerne des anticorps régulés par les protéases, qui se lient spécifiquement à l'inhibiteur de la voie du facteur tissulaire (TFPI). Les anticorps de l'invention sont utiles pour le traitement de troubles de saignement, tels que l'hémophilie.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)