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1. (WO2013148202) NOVEL COMPOSITIONS AND METHODS FOR PREVENTING OR TREATING CANCER METASTASIS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/148202 International Application No.: PCT/US2013/030906
Publication Date: 03.10.2013 International Filing Date: 13.03.2013
IPC:
C12Q 1/00 (2006.01) ,G01N 33/53 (2006.01) ,C12Q 1/68 (2006.01) ,G01N 33/48 (2006.01) ,A61K 39/395 (2006.01)
Applicants: PHILADELPHIA HEALTH AND EDUCATION CORPORATION, D/B/A DREXEL UNIVERSITY COLLEGE OF MEDICINE[US/US]; 245 N. 15th Street Philadelphia, PA 19102, US
Inventors: FATATIS, Alessandro; US
RUSSELL, Michael; US
LUI, Qingxin ( Cindy); US
Agent: SILVA, Domingos, J.; Riverside Law, LLP 300 Four Falls Corporate Center, Suite 710 300 Conshohocken State Road West Conshohocken, PA 19428, US
Priority Data:
61/617,44729.03.2012US
61/650,89123.05.2012US
Title (EN) NOVEL COMPOSITIONS AND METHODS FOR PREVENTING OR TREATING CANCER METASTASIS
(FR) NOUVELLES COMPOSITIONS ET NOUVELLES MÉTHODES DE PRÉVENTION OU DE TRAITEMENT DE LA MÉTASTASE DU CANCER
Abstract: front page image
(EN) The invention includes a method of preventing or treating metastasis in a subject diagnosed with cancer, comprising determining whether at least one gene encoding one or more proteins is upregulated in a cancer tissue sample from the subject as compared to the level of expression of the at least one gene in a non-cancer control sample of the same tissue, and, if the at least one gene is upregulated in the cancer tissue sample from the subject, administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising one or more protein depleting agents.
(FR) L'invention concerne une méthode de prévention ou de traitement de la métastase chez un sujet diagnostiqué d'un cancer, consistant à déterminer si au moins un gène codant pour une ou plusieurs protéines est régulé de façon positive dans un échantillon de tissu cancéreux provenant du sujet en comparaison au niveau d'expression du au moins un gène dans un échantillon témoin non cancéreux du même tissu, et, si le au moins un gène est régulé de façon positive dans l'échantillon de tissu cancéreux provenant du sujet, l'administration au sujet d'une quantité thérapeutiquement efficace d'une composition pharmaceutique comprenant un ou plusieurs agents de déplétion de protéine.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)