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Machine translation
1. (WO2013147793) METHODS AND COMPOSITIONS FOR MODULATING NOTCH ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/147793    International Application No.:    PCT/US2012/031213
Publication Date: 03.10.2013 International Filing Date: 29.03.2012
IPC:
A61P 35/00 (2006.01), A61K 39/395 (2006.01), C07K 14/00 (2006.01)
Applicants: FLEMING, Robert, J. [US/US]; (US).
ARTAVANIS-TSAKONAS, Spyridon [US/US]; (US)
Inventors: FLEMING, Robert, J.; (US).
ARTAVANIS-TSAKONAS, Spyridon; (US)
Agent: ANTLER, Adriane, M.; Jones Day 222 East 41st Street New York, NY 10017-6702 (US)
Priority Data:
Title (EN) METHODS AND COMPOSITIONS FOR MODULATING NOTCH ACTIVITY
(FR) MÉTHODES ET COMPOSITIONS UTILISÉES POUR MODULER L'ACTIVITÉ NOTCH
Abstract: front page image
(EN)Provided herein are polypeptides and derivatives thereof that contain sequences of a Serrate protein and that inhibit Notch pathway function. Also provided herein are nucleic acids that encode the polypeptides, vectors and cells for producing the polypeptides, and related pharmaceutical compositions and kits. Additionally provided are antibodies which bind to the Notch inhibitory region of a Serrate protein. Therapeutic methods are also provided.
(FR)Cette invention concerne des polypeptides et leurs dérivés qui contiennent des séquences d'une protéine Serrate et qui inhibent la voie de signalisation Notch. L'invention concerne aussi des acides nucléiques codant pour ces polypeptides, des vecteurs et des cellules permettant de produire ces polypeptides, et des compositions pharmaceutiques et des kits associés. L'invention concerne également des anticorps qui se lient à la région inhibitrice Notch d'une protéine Serrate. Des méthodes thérapeutiques sont aussi décrites.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)