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1. (WO2013147749) ORAL COMBINATION THERAPY FOR TREATING HCV INFECTION IN SPECIFIC PATIENT SUBGENOTYPE POPULATIONS

Pub. No.:    WO/2013/147749    International Application No.:    PCT/US2012/030692
Publication Date: Fri Oct 04 01:59:59 CEST 2013 International Filing Date: Wed Mar 28 01:59:59 CEST 2012
IPC: A61K 31/4709
A61K 31/506
C12Q 1/68
Applicants: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
MENSA, Federico
NEHMIZ, Gerhard
Inventors: MENSA, Federico
NEHMIZ, Gerhard
Title: ORAL COMBINATION THERAPY FOR TREATING HCV INFECTION IN SPECIFIC PATIENT SUBGENOTYPE POPULATIONS
Abstract:
The present invention relates to therapeutic combinations comprising (a) Compound (1), or a pharmaceutically acceptable salt thereof, as herein described, (b) Compound (2), or a pharmaceutically acceptable salt thereof, as herein described, and optionally (c) ribavirin, and methods of using such therapeutic combinations for treating HCV infection or alleviating one or more symptoms thereof in a patient that has genetic variations located near the IL28B gene, including SNP rs 12979860 with a CC or non-CC genotype and SNP rs 8099917 with a TT or non-TT genotype.