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1. (WO2013146734) ANTICANCER AGENT
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/146734 International Application No.: PCT/JP2013/058692
Publication Date: 03.10.2013 International Filing Date: 26.03.2013
IPC:
A61K 31/341 (2006.01) ,A61K 31/7034 (2006.01) ,A61K 36/00 (2006.01) ,A61K 36/28 (2006.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
34
having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
341
not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7028
Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7034
attached to a carbocyclic compound, e.g. phloridzin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36
Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36
Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18
Magnoliophyta (angiosperms)
185
Magnoliopsida (dicotyledons)
28
Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
クラシエ製薬株式会社 KRACIE PHARMA, LTD. [JP/JP]; 東京都港区海岸3丁目20番20号 20-20, Kaigan 3-chome, Minato-ku, Tokyo 1088080, JP
独立行政法人国立がん研究センター NATIONAL CANCER CENTER [JP/JP]; 東京都中央区築地5丁目1番1号 1-1, Tsukiji 5-chome, Chuo-ku, Tokyo 1040045, JP
国立大学法人富山大学 NATIONAL UNIVERSITY CORPORATION UNIVERSITY OF TOYAMA [JP/JP]; 富山県富山市五福3190 3190 Gofuku, Toyama-shi, Toyama 9308555, JP
Inventors:
江角 浩安 ESUMI Hiroyasu; JP
池田 公史 IKEDA Masafumi; JP
三好 千香 MIYOSHI Chika; JP
門田 重利 KADOTA Shigetoshi; JP
大窪 敏樹 OKUBO Toshiki; JP
与茂田 敏 YOMODA Satoshi; JP
布施 貴史 FUSE Takafumi; JP
川島 孝則 KAWASHIMA Takanori; JP
千葉 殖幹 CHIBA Shigeki; JP
Agent:
相原 礼路 AIHARA, Reiji; 東京都調布市布田四丁目19番地1 ライオンズプラザ調布305 305, LIONS PLAZA CHOFU, 19-1, Fuda 4-chome, Chofu-shi Tokyo 1820024, JP
Priority Data:
2012-06996426.03.2012JP
Title (EN) ANTICANCER AGENT
(FR) MÉDICAMENT ANTICANCÉREUX
(JA) 抗癌剤
Abstract:
(EN) The purpose of the present invention is to provide a novel anticancer agent effective against cancer. When an agent prepared using an extract of Arctium lappa seeds was injected into a pancreatic cancer patients such that the daily dose of arctigenin was 100mg or greater, a tumor shrinkage effect was observed and a decrease in tumor markers was confirmed. The present invention provides an anticancer agent containing arctigenin such that the daily dose is 100mg or greater. Further, the present invention provides an anticancer agent containing arctigenin and arctiin in a weight ratio arctigenin / arctiin = 0.7-1.3.
(FR) L'invention a pour objectif de fournir un nouveau médicament anticancéreux efficace contre le cancer. Lorsqu'un médicament préparé à l'aide d'un extrait de fruit de bardane, est administré à un patient atteint du cancer du pancréas, de sorte que la quantité administrée d'arctigenine par jour soit supérieure ou égale à 100mg, une réduction de la tumeur est observée, et une diminution de marqueurs tumoraux est confirmée. Le médicament anticancéreux de l'invention comprend une arctigenine de sorte que la quantité administrée par jour soit supérieure ou égale à 100mg. Enfin, le médicament anticancéreux de l'invention comprend l'arctigenine et une arctiine dans un rapport massique tel que arctigenine/arctiine =0,7/1,3.
(JA)  本発明は、癌に対して効果を有する新規な抗癌剤を提供することを目的とする。ゴボウシ抽出物を用いて調製した剤を、アルクチゲニンの1日あたりの投与量が100mg以上となるように膵臓癌患者に投与したところ、腫瘍縮小効果が見られ、また腫瘍マーカーの低下が確認された。本発明は、アルクチゲニンを1日あたりの投与量が100mg以上となるように含有する、抗癌剤を提供する。また、本発明は、アルクチゲニンおよびアルクチインを、アルクチゲニン/アルクチイン=0.7~1.3の重量比にて含有する、抗癌剤を提供する。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)