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1. (WO2013144566) ANIMALS EXPRESSING HUMAN LAMBDA IMMUNOGLOBULIN LIGHT CHAIN VARIABLE DOMAIN
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/144566 International Application No.: PCT/GB2013/050682
Publication Date: 03.10.2013 International Filing Date: 18.03.2013
IPC:
C12N 15/85 (2006.01) ,A01K 67/027 (2006.01) ,C07K 16/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
K
ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67
Rearing or breeding animals, not otherwise provided for; New breeds of animals
027
New breeds of vertebrates
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
Applicants: KYMAB LIMITED[GB/GB]; Meditrina (B206) Babraham Research Campus Cambridge Cambridgeshire CB22 3AT, GB
Inventors: BRADLEY, Allan; GB
LEE, E-Chiang; GB
LIANG, Qi; GB
WANG, Wei; GB
SPENSBERGER, Dominik; GB
LIU, Hui; GB
CLUBE, Jasper; GB
Agent: STEPHEN, Robert; 90 High Holborn London Greater London WC1V 6XX, GB
Priority Data:
13/433,08428.03.2012US
13/434,36129.03.2012US
Title (EN) ANIMALS EXPRESSING HUMAN LAMBDA IMMUNOGLOBULIN LIGHT CHAIN VARIABLE DOMAIN
(FR) MODÈLES ANIMAUX ET MOLÉCULES THÉRAPEUTIQUES
Abstract:
(EN) The invention discloses methods for the generation of chimaeric human – non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
(FR) La présente invention concerne des méthodes pour générer des anticorps chimères humains-non humains et des chaînes d'anticorps chimères, les anticorps et les chaînes d'anticorps ainsi produits et leurs dérivés comprenant des anticorps totalement humanisés; des compositions comprenant lesdits anticorps, chaînes d'anticorps et dérivés, ainsi que des cellules, des mammifères non humains et des vecteurs, appropriés pour être utilisés dans lesdites méthodes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)