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1. (WO2013144563) TREATMENT OF ACUTE INFLAMMATION IN THE RESPIRATORY TRACT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/144563    International Application No.:    PCT/GB2013/050665
Publication Date: 03.10.2013 International Filing Date: 15.03.2013
IPC:
A61K 39/395 (2006.01), C07K 16/28 (2006.01), A61K 31/443 (2006.01)
Applicants: UCL BUSINESS PLC [GB/GB]; The Network Building 97 Tottenham Court Road London W1T 4TP (GB)
Inventors: CHAMBERS, Rachel; (GB).
MERCER, Paul; (GB).
WILLIAMS, Andrew; (GB)
Agent: BENTHAM, Andrew; J A Kemp 14 South Square Gray's Inn London WC1R 5JJ (GB)
Priority Data:
1205739.4 30.03.2012 GB
Title (EN) TREATMENT OF ACUTE INFLAMMATION IN THE RESPIRATORY TRACT
(FR) TRAITEMENT D'UNE INFLAMMATION AIGUË DANS LES VOIES RESPIRATOIRES
Abstract: front page image
(EN)This invention relates to the field of molecular physiology. Specifically, this invention relates to the prevention and/or treatment of acute inflammation of the respiratory tract, especially acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Levels of CCL7 have been demonstrated to be increased in patients suffering from such conditions and animal models of such conditions. Antagonists of CCL7 and/or other members of the PAR1-CCL7 axis,or CCL2can be used to prevent and/or treat these conditions.
(FR)La présente invention concerne le domaine de la physiologie moléculaire. Spécifiquement, cette invention concerne la prévention et/ou le traitement d'une inflammation aiguë des voies respiratoires, en particulier une lésion pulmonaire aiguë (LPA) ou le syndrome de détresse respiratoire aiguë (SDRA). Il a été démontré que les niveaux de CCL7 augmentaient chez des patients souffrant de tels états pathologiques et des modèles animaux de tels états pathologiques. Des antagonistes de CCL7 et/ou d'autres éléments de l'axe PAR1-CCL7, ou CCL2 peuvent être utilisés pour prévenir et/ou traiter ces états pathologiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)