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1. (WO2013144339) FGFR INHIBITOR FOR USE IN THE TREATMENT OF HYPOPHOSPHATEMIC DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/144339    International Application No.:    PCT/EP2013/056811
Publication Date: 03.10.2013 International Filing Date: 29.03.2013
IPC:
A61K 31/506 (2006.01), A61P 19/08 (2006.01)
Applicants: NOVARTIS AG [CH/CH]; Lichtstrasse 35 CH-4056 Basel (CH) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
KNEISSEL, Michaela [AT/CH]; (CH) (US only).
GUAGNANO, Vito [IT/CH]; (CH) (US only).
GRAUS PORTA, Diana [ES/CH]; (CH) (US only).
WÖHRLE, Simon [DE/DE]; (DE) (US only)
Inventors: KNEISSEL, Michaela; (CH).
GUAGNANO, Vito; (CH).
GRAUS PORTA, Diana; (CH).
WÖHRLE, Simon; (DE)
Agent: PFISTER-FU, Yixin; Novartis Pharma Ag Patent Department CH-4002 Basel (CH)
Priority Data:
61/617,889 30.03.2012 US
Title (EN) FGFR INHIBITOR FOR USE IN THE TREATMENT OF HYPOPHOSPHATEMIC DISORDERS
(FR) INHIBITEUR DE FGFR DESTINÉ AU TRAITEMENT DE TROUBLES HYPOPHOSPHATÉMIQUES
Abstract: front page image
(EN)The present invention relates generally to 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimid-4-yl}-l-methyl-urea or a pharmaceutically acceptable salt or solvate thereof or a pharmaceutical composition comprising 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimid-4-yl}-1-methyl-urea or a pharmaceutically acceptable salt or solvate thereof for use in the treatment of X-linked hypophosphatemic rickets (XLH), autosomal dominant hypophosphatemic rickets (ADHR), autosomal recessive hypophosphatemic rickets (ARHR), tumor-induced osteomalacia, post-renal transplant hypophosphatemia, epidermal nevus syndrome, osteoglophonic dysplasia or McCune-Albright syndrome.
(FR)La présente invention concerne d'une manière générale 3- (2,6-dichloro-3,5-diméthoxy-phényl)-1- {6- [4-(4-éthyl-pipérazin-1-yl) -phénylamino]-pyrimid-4-yl}-l-méthyl-urée ou un sel pharmaceutiquement acceptable ou un solvate pharmaceutiquement acceptable de celui-ci ou bien une composition pharmaceutique comprenant 3- (2,6-dichloro -3,5-diméthoxy-phényl)-1-{6-[4-(4-éthyl-pipérazin-1-yl)-phénylamino]-pyrimid-4-yl}-1-méthyl-urée ou un sel pharmaceutiquement acceptable ou un solvate pharmaceutiquement acceptable de celui-ci pour le traitement du rachitisme hypophosphatémique lié à l'X (XLH), du rachitisme hypophosphatémique autosomique dominant (ADHR), du rachitisme hypophosphatémique autosomique récessif (ARHR), de l'ostéomalacie induite par une tumeur, de l'hypophosphatémie suivant la greffe d'un rein, du syndrome de naevus épidermique, de la dysplasie ostéoglophonique ou du syndrome de McCune-Albright.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)