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1. (WO2013143683) RNA FORMULATION FOR IMMUNOTHERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/143683 International Application No.: PCT/EP2013/000902
Publication Date: 03.10.2013 International Filing Date: 25.03.2013
IPC:
A61K 9/127 (2006.01) ,A61K 39/00 (2006.01) ,A61K 48/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Applicants: BIONTECH AG[DE/DE]; An der Goldgrube 12 55131 Mainz, DE
TRON - TRANSLATIONALE ONKOLOGIE AN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ GEMEINNÜTZIGE GMBH[DE/DE]; Langenbeckstrasse 1 55131 Mainz, DE
UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ[DE/DE]; Langenbeckstrasse 1 55131 Mainz, DE
Inventors: SAHIN, Ugur; DE
HAAS, Heinrich; DE
KREITER, Sebastian; DE
DIKEN, Mustafa; DE
FRITZ, Daniel; DE
MENG, Martin; DE
KRANZ, Lena, Mareen; DE
REUTER, Kerstin; DE
Agent: SCHNAPPAUF, Georg; ZSP Patentanwälte Partnerschaftsgesellschaft Radlkoferstrasse 2 81373 München, DE
Priority Data:
PCT/EP2012/00131926.03.2012EP
Title (EN) RNA FORMULATION FOR IMMUNOTHERAPY
(FR) FORMULATION D'ARN POUR L'IMMUNOTHÉRAPIE
Abstract:
(EN) The present invention is in the field of immunotherapy, in particular tumor immunotherapy. The present invention provides pharmaceutical formulations for delivering RNA to antigen presenting cells such as dendrite cells (DCs) in the spleen after systemic administration. In particular, the formulations described herein enable to induce an immune response after systemic administration of antigen-coding RNA.
(FR) La présente invention concerne le domaine de l'immunothérapie, en particulier de l'immunothérapie antitumorale. La présente invention concerne des formulations pharmaceutiques pour l'administration d'ARN à des cellules présentatrices d'antigène, telles que des cellules dendritiques (DC), dans la rate après une administration systémique. En particulier, les formulations décrites ici permettent d'induire une réponse immunitaire après une administration systémique d'un ARN codant pour un antigène.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)