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1. (WO2013143322) METHOD FOR DISSOLVING FLAVONOID COMPOUND, CARBON GLYCOSIDE COMPOUND, OR STILBENE COMPOUND AND METHOD FOR PREPARING INJECTION OR POWDER FOR INJECTION

Pub. No.:    WO/2013/143322    International Application No.:    PCT/CN2012/086443
Publication Date: Fri Oct 04 01:59:59 CEST 2013 International Filing Date: Thu Dec 13 00:59:59 CET 2012
IPC: A61K 9/08
A61K 9/19
A61K 47/22
A61K 47/10
A61P 1/16
A61P 29/00
A61P 5/30
A61P 31/04
A61P 31/12
A61P 35/00
A61P 39/06
A61P 9/10
A61P 9/00
A61P 9/06
A61P 7/02
Applicants: KUNMING PHARMACEUTICAL CORP.
昆明制药集团股份有限公司
Inventors: CHEN, Yunjian
陈云建
YANG, Zhaoxiang
杨兆祥
ZHU, Ze
朱泽
FANG, Fang
方芳
PU, Junxue
普俊学
Title: METHOD FOR DISSOLVING FLAVONOID COMPOUND, CARBON GLYCOSIDE COMPOUND, OR STILBENE COMPOUND AND METHOD FOR PREPARING INJECTION OR POWDER FOR INJECTION
Abstract:
The present invention relates to the technical field of medicine, and relates specifically to a method for dissolving a flavonoid compound, a carbon glycoside compound, or a stilbene compound and a method for preparing an injection or a powder for injection. The method: the flavonoid compound, the carbon glycoside compound, or the stilbene compound is mixed with a solubilizer to acquire a reactant; when water for injection is heated and stirred in a vacuum, the reactant is added under the protection of nitrogen or argon to acquire a product. The dissolution speed of the method is fast, redissolution tests show that a freeze-dried powder that is acquired when a water-soluble medicament acquired is freeze-dried can dissolve completely in just five seconds, a significant increase in redissolution speed compared with a control group; also, the stability is great, and a medicinal requirement for clinical emergencies is satisfied.