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1. (WO2013143259) PHOSPHODIESTERASE-4 INHIBITOR CAPABLE OF AVOIDING VOMIT REACTION AND PREPARATION METHOD FOR SAME

Pub. No.:    WO/2013/143259    International Application No.:    PCT/CN2012/080974
Publication Date: Fri Oct 04 01:59:59 CEST 2013 International Filing Date: Wed Sep 05 01:59:59 CEST 2012
IPC: C07D 307/20
A61K 31/341
A61P 25/28
A61P 25/24
Applicants: XU, Jiangping
徐江平
Inventors: XU, Jiangping
徐江平
ZHOU, Zhongzhen
周中振
CHENG, Yufang
程玉芳
ZHANG, Mingzi
张明子
Title: PHOSPHODIESTERASE-4 INHIBITOR CAPABLE OF AVOIDING VOMIT REACTION AND PREPARATION METHOD FOR SAME
Abstract:
The present invention relates to a phosphodiesterase-4 inhibitor capable of avoiding a vomit reaction. The phosphodiesterase-4 inhibitor is a compound, a prodrug or a solvate represented by DTPM. The name of DTPM is 1-(4-difluoro methoxy-3-(tetrahydrofuran-3-oxyl)phenyl)-3-dimethyl-1-ketone, and a chemical formula is shown in formula (I). The compound in the present invention can prepare a drug that can effectively weaken or even avoid an adverse reaction such as vomit, can treat depression and alzheimer disease and can improve cognitive competence.