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10. (WO2013141750) SYNTHETIC PEPTIDES WTIH A NON-NARCOTIC TYPE OF ANALGESIC EFFECT

Pub. No.:    WO/2013/141750    International Application No.:    PCT/RU2012/001036
Publication Date: Fri Sep 27 01:59:59 CEST 2013 International Filing Date: Sat Dec 08 00:59:59 CET 2012
IPC: C07K 7/06
A61K 38/08
A61P 29/00
Applicants: KOTIN, Oleg Arkadyevich
КОТИН, Олег Аркадьевич
VLASOV, Gennady Petrovich
ВЛАСОВ, Геннадий Петрович
KOTIN, Arkadiy Mihajlovich
КОТИН, Аркадий Михайлович
Inventors: VLASOV, Gennady Petrovich
ВЛАСОВ, Геннадий Петрович
KOTIN, Arkadiy Mihajlovich
КОТИН, Аркадий Михайлович
Title: SYNTHETIC PEPTIDES WTIH A NON-NARCOTIC TYPE OF ANALGESIC EFFECT
Abstract:
What are proposed are: synthetic peptides having a non-narcotic type of analgesic effect, of general formula 1 [SEQ ID NO:1], where: H is hydrogen, XDL is an omission of an amino acid or is L-Tyr, XDL1 is one of the following amino acids: L-Leu, L-Ala or D-Ala, XDL2 is one of the following amino acids: L-His, D-His, L-Ala or D-Ala, XDL3 is one of the following amino acids: L-Gln, L-Ala or D-Ala; R2 is ОМе or NH2, and also retro-inversion peptides of formula (I), having a reverse sequence of amino acids with L-shaped amino acids being substituted by D-shaped amino acids, and D-shaped amino acids being substituted by L-shaped amino acids, of general formula 2 [SEQ ID NO:2], where: H is hydrogen, XDL4 is one of the following amino acids: D-GIn, D-Ala or L-Ala, XDL5 is one of the following amino acids: D-His, L-His, D-Ala or L-Ala, XDL6 is one of the following amino acids: D-Leu, D-Ala or L-Ala, XDL7 is an omission of an amino acid or is D-Tyr, R2 is ОМе or NH2.