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10. (WO2013141750) SYNTHETIC PEPTIDES WTIH A NON-NARCOTIC TYPE OF ANALGESIC EFFECT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/141750    International Application No.:    PCT/RU2012/001036
Publication Date: 26.09.2013 International Filing Date: 07.12.2012
IPC:
C07K 7/06 (2006.01), A61K 38/08 (2006.01), A61P 29/00 (2006.01)
Applicants: KOTIN, Oleg Arkadyevich [RU/RU]; (RU).
VLASOV, Gennady Petrovich [RU/RU]; (RU) (US only).
KOTIN, Arkadiy Mihajlovich [RU/RU]; (RU) (US only)
Inventors: VLASOV, Gennady Petrovich; (RU).
KOTIN, Arkadiy Mihajlovich; (RU)
Agent: CLOSED CORPORATION THE UNIVERSAL CONSULTING COMPANY OF INDEPENDET PATENT ATTORNEYS AND LAWYERS "LEV KLIMENKO"; Sosinskaya, 43, 1 Moscow, 109316 (RU)
Priority Data:
2012110908 22.03.2012 RU
Title (EN) SYNTHETIC PEPTIDES WTIH A NON-NARCOTIC TYPE OF ANALGESIC EFFECT
(FR) PEPTIDES SYNTHÉTIQUES À TYPE D'ACTION ANALGÉSIQUE NON NARCOTIQUE
(RU) СИНТЕТИЧЕСКИЕ ПЕПТИДЫ С НЕНАРКОТИЧЕСКИМ ТИПОМ АНАЛЬГЕТИЧЕСКОГО ДЕЙСТВИЯ
Abstract: front page image
(EN)What are proposed are: synthetic peptides having a non-narcotic type of analgesic effect, of general formula 1 [SEQ ID NO:1], where: H is hydrogen, XDL is an omission of an amino acid or is L-Tyr, XDL1 is one of the following amino acids: L-Leu, L-Ala or D-Ala, XDL2 is one of the following amino acids: L-His, D-His, L-Ala or D-Ala, XDL3 is one of the following amino acids: L-Gln, L-Ala or D-Ala; R2 is ОМе or NH2, and also retro-inversion peptides of formula (I), having a reverse sequence of amino acids with L-shaped amino acids being substituted by D-shaped amino acids, and D-shaped amino acids being substituted by L-shaped amino acids, of general formula 2 [SEQ ID NO:2], where: H is hydrogen, XDL4 is one of the following amino acids: D-GIn, D-Ala or L-Ala, XDL5 is one of the following amino acids: D-His, L-His, D-Ala or L-Ala, XDL6 is one of the following amino acids: D-Leu, D-Ala or L-Ala, XDL7 is an omission of an amino acid or is D-Tyr, R2 is ОМе or NH2.
(FR)L'invention porte sur des peptides synthétiques à type d'action analgésique non narcotique possédant une formule générale 1 [SEQ ID NO:1] dans laquelle : H est hydrogène, XDL est une absence d'acide aminé ou L-Tyr, XDL1 est un d'acides aminés : L-Leu, L-Ala ou D-Ala, XDL2 est un d'acides aminés : L-His, D-His, L-Ala ou D-Ala, XDL3 est un d'acides aminés : L-Gln, L-Ala ou D-Ala; R2 - ОМе ou NH2, ainsi que des peptides de rétro-inversion de la formule (I) possédant une séquence inverse d'acides aminés avec remplacement de la forme L d'acides aminés par une forme D et de forme D d'acides aminés par une forme L de la formule générale 2 [SEQ ID NO:2] dans laquelle : H est hydrogène, XDL4 est un d'acides aminés : D-GIn, D-Ala ou L-Ala, XDL5 est un d'acides aminés : D-His, L-His, D-Ala ou L-Ala, XDL6 est un d'acides aminés : D-Leu, D-Ala ou L-Ala, XDL7 est une absence d'acide aminé ou D-Tyr, R2 - ОМе ou NH2.
(RU)Предложены синтетические пептиды, обладающие ненаркотическим типом анальгетического действия, общей формулы 1 [SEQ ID NO:1], где: H - водород, XDL - отсутствие аминокислоты или L-Tyr, XDL1 - одна из аминокислот: L-Leu, L-Ala или D-Ala, XDL2 - одна из аминокислот: L-His, D-His, L-Ala или D-Ala, XDL3 - одна из аминокислот: L-Gln, L-Ala или D-Ala; R2 - ОМе или NH2, а также пептиды - ретроинверсии формулы (I), имеющие обратную последовательность аминокислот с заменой L-формы аминокислот на D-форму и D-формы аминокислот на L-форму, общей формулы 2 [SEQ ID NO:2], где: H - водород, XDL4 - одна из аминокислот: D-GIn, D-Ala или L-Ala, XDL5 - одна из аминокислот: D-His, L-His, D-Ala или L-Ala, XDL6 - одна из аминокислот: D-Leu, D-Ala или L-Ala, XDL7 - отсутствие аминокислоты или D-Tyr, R2 - ОМе или NH2.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Russian (RU)
Filing Language: Russian (RU)