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1. WO2013138428 - A FRAMEWORK FOR PERSONALIZATION OF CORONARY FLOW COMPUTATIONS DURING REST AND HYPEREMIA

Publication Number WO/2013/138428
Publication Date 19.09.2013
International Application No. PCT/US2013/030732
International Filing Date 13.03.2013
IPC
A61B 5/026 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
02Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
026Measuring blood flow
G06F 19/00 2011.01
GPHYSICS
06COMPUTING; CALCULATING OR COUNTING
FELECTRIC DIGITAL DATA PROCESSING
19Digital computing or data processing equipment or methods, specially adapted for specific applications
A61B 5/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
02Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
A61B 5/022 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
02Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
021Measuring pressure in heart or blood vessels
022by applying pressure to close blood vessels, e.g. against the skin; Ophthaldynamometers
A61B 5/024 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
02Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
024Measuring pulse rate or heart rate
CPC
A61B 5/02007
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
02007Evaluating blood vessel condition, e.g. elasticity, compliance
A61B 5/02028
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
02028Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
A61B 5/021
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
021Measuring pressure in heart or blood vessels
A61B 5/022
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
021Measuring pressure in heart or blood vessels
022by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
A61B 5/024
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
024Detecting, measuring or recording pulse rate or heart rate
A61B 5/026
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
026Measuring blood flow
Applicants
  • SIEMENS AKTIENGESELLSCHAFT [DE]/[DE] (AllExceptUS)
  • ITU, Lucian, Mihai [RO]/[RO] (US)
  • SHARMA, Puneet [IN]/[US] (US)
  • ZHENG, Xudong [CN]/[US] (US)
  • KAMEN, Ali [US]/[US] (US)
  • SUCIU, Constantin [RO]/[RO] (US)
  • COMANICIU, Dorin [US]/[US] (US)
Inventors
  • ITU, Lucian, Mihai
  • SHARMA, Puneet
  • ZHENG, Xudong
  • KAMEN, Ali
  • SUCIU, Constantin
  • COMANICIU, Dorin
Agents
  • CONOVER, Michele, L.
Priority Data
61/611,21015.03.2012US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) A FRAMEWORK FOR PERSONALIZATION OF CORONARY FLOW COMPUTATIONS DURING REST AND HYPEREMIA
(FR) CADRE POUR LA PERSONNALISATION DE CALCULS DE DÉBIT CORONAIRE PENDANT LE REPOS ET L'HYPERÉMIE
Abstract
(EN)
Embodiments relate to non-invasively determining coronary circulation parameters during a rest state and a hyperemic state for a patient. The blood flow in the coronary arteries during a hyperemic state provides a functional assessment of the patient's coronary vessel tree. Imaging techniques are used to obtain an anatomical model of the patient's coronary tree. Rest boundary conditions are computed based on non-invasive measurements taken at a rest state, and estimated hyperemic boundary conditions are computed. A feedback control system performs a simulation matching the rest state utilizing a model based on the anatomical model and a plurality of controllers, each controller relating to respective output variables of the coronary tree. The model parameters are adjusted for the output variables to be in agreement with the rest state measurements, and the hyperemic boundary conditions are accordingly adjusted. The hyperemic boundary conditions are used to compute coronary flow and coronary pressure variables.
(FR)
La présente invention concerne, dans certains modes de réalisation, la détermination non invasive de paramètres de circulation coronaire durant un état de repos et un état d'hyperémie pour un patient. Le débit sanguin dans les artères coronaires durant l'état d'hyperémie procure une évaluation fonctionnelle de l'arbre coronaire du patient. Des techniques d'imagerie sont utilisées pour obtenir un modèle anatomique de l'arbre coronaire dudit patient. Les conditions limites du repos sont calculées sur la base de mesures non invasives prises lors d'un état de repos, et une estimation des conditions limites d'hyperémie est calculée. Un système de commande de rétroaction réalise une simulation correspondant à l'état de repos en utilisant un modèle basé sur le modèle anatomique et une pluralité de dispositifs de contrôle, chaque dispositif de contrôle étant lié à des variables de sortie respectives de l'arbre coronaire. Les paramètres du modèle sont adaptés pour que les variables de sortie concordent avec les mesures de l'état de repos, et les conditions limites de l'hyperémie sont adaptées en conséquence. Les conditions limites d'hyperémie sont utilisées pour calculer les variables de débit coronaire et de pression coronaire.
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