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1. WO2013134742 - MICRO-TUBE PARTICLES FOR MICROFLUIDIC ASSAYS AND METHODS OF MANUFACTURE

Publication Number WO/2013/134742
Publication Date 12.09.2013
International Application No. PCT/US2013/030054
International Filing Date 08.03.2013
IPC
B01L 3/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
B01J 19/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19Chemical, physical or physico-chemical processes in general; Their relevant apparatus
G01N 35/00 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
35Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/-G01N33/148; Handling materials therefor
CPC
B01J 19/0046
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19Chemical, physical or physico-chemical processes in general; Their relevant apparatus
0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
B01J 2219/00468
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00277Apparatus
00457Dispensing or evacuation of the solid phase support
00459Beads
00468by manipulation of individual beads
B01J 2219/00511
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00277Apparatus
00497Features relating to the solid phase supports
00511Walls of reactor vessels
B01J 2219/0052
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00277Apparatus
00497Features relating to the solid phase supports
00513Essentially linear supports
0052in the shape of elongated tubes
B01J 2219/00522
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00277Apparatus
00497Features relating to the solid phase supports
00513Essentially linear supports
0052in the shape of elongated tubes
00522in a multiple parallel arrangement
B01J 2219/0054
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00277Apparatus
0054Means for coding or tagging the apparatus or the reagents
Applicants
  • CYVEK, INC [US]/[US]
Inventors
  • PUTNAM, Martin, A.
  • BRANCIFORTE, Jeffrey, T.
  • STANWOOD, Charles, O.
  • TU, Jane, M.
Agents
  • DEPRADO, Gerald L.
Priority Data
13/427,85722.03.2012US
61/608,57008.03.2012US
61/754,37718.01.2013US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MICRO-TUBE PARTICLES FOR MICROFLUIDIC ASSAYS AND METHODS OF MANUFACTURE
(FR) PARTICULES MICRO-TUBULAIRES POUR ANALYSES MICROFLUIDIQUES ET PROCÉDÉS DE FABRICATION
Abstract
(EN)
A microfluidic assay device that defines a micro-fluidic flow channel (44) having a flow axis, in which a series of discrete, axially-spaced apart, transparent hollow flow elements (32) are secured in fixed position, each flow element having at least one axially-extending flow passage through its interior, assay capture agent fixed to the interior surface of the elements for capture of an analyte in liquid flowing through the interior of the flow elements, the device constructed to enable light to be transmitted out of the elements for reading of fluorescence from captured analyte, wherein: the exterior axially-extending surfaces of the flow elements are free of active capture agent, while at least part of the interior surfaces carry deposits of active capture agent exposed to flow through the elements.
(FR)
L'invention concerne un dispositif d'analyse microfluidique qui définit un canal d'écoulement microfluidique (44) possédant un axe d'écoulement, dans lequel une série d'éléments d'écoulement creux, transparents et espacés axialement (32) sont maintenus en position fixe, chaque élément d'écoulement étant traversé par au moins un passage d'écoulement s'étendant dans le sens axial, un agent de capture d'analyse fixé sur la surface intérieure des éléments pour la capture d'un analyte dans le liquide s'écoulant à l'intérieur des éléments d'écoulement, le dispositif étant conçu pour permettre la transmission de la lumière par les éléments en vue de la lecture de la fluorescence provenant de l'analyte capturé. Les surfaces extérieures s'étendant axialement des éléments d'écoulement sont exemptes d'agent de capture actif, alors qu'au moins une partie des surfaces intérieures transportent des dépôts d'agent de capture actif exposé au flux au travers des éléments.
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