Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
95. (WO2013130411) SALTS OF POTASSIUM ATP CHANNEL OPENERS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/130411 International Application No.: PCT/US2013/027676
Publication Date: 06.09.2013 International Filing Date: 25.02.2013
IPC:
A61K 31/549 (2006.01) ,A61K 31/38 (2006.01) ,A61P 3/00 (2006.01) ,A61P 9/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
54
having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
549
having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
38
having sulfur as a ring hetero atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
Applicants:
ESSENTIALIS, INC. [US/US]; 9393 Towne Centre Drive, Suite 200 San Diego, CA 92121, US
Inventors:
COWEN, Neil, M.; US
PASTERNARK, Richard, C.; US
Agent:
KUHLMANN, Anthony; Sheppard Mullin Richter & Hampton LLP 12275 El Camino Real, Suite 200 San Diego, CA 92130, US
Priority Data:
61/603,92327.02.2012US
Title (EN) SALTS OF POTASSIUM ATP CHANNEL OPENERS AND USES THEREOF
(FR) SELS D'OUVREURS DES CANAUX POTASSIQUES ATP ET LEURS UTILISATIONS
Abstract:
(EN) Provided are immediate or prolonged administration of certain salts of KATP channel openers such as diazoxide to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving KATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of the salts that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are method of co-administering the salts with other drugs to treat diseases of humans and animals.
(FR) L'invention concerne l'administration immédiate ou prolongée de certains sels d'ouvreurs des canaux KATP, tels que le diazoxyde, à un sujet pour obtenir de nouveaux résultats pharmacodynamique, pharmacocinétique, thérapeutique, physiologique, métabolique et de composition dans le traitement de maladies ou d'états impliquant des canaux KATP. L'invention concerne également des formulations pharmaceutiques, des procédés d'administration et de dosage des sels qui obtiennent ces résultats et réduisent l'incidence d'effets indésirables chez des individus traités. L'invention concerne en outre un procédé de co-administration des sels avec d'autres médicaments pour traiter des maladies chez des êtres humains et des animaux.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)