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1. (WO2013127196) MELANOCYTE-STIMULATING HORMONE ANALOGUE FORMED BY CONNECTING CIRCULAR CORE SEQUENCE AND BIOTIN OR MEMBRANE-PENETRATING PEPTIDE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2013/127196 International Application No.: PCT/CN2012/084555
Publication Date: 06.09.2013 International Filing Date: 14.11.2012
IPC:
C07K 7/64 (2006.01) ,C07K 1/06 (2006.01) ,C07K 1/04 (2006.01) ,A61K 38/12 (2006.01) ,A61P 15/10 (2006.01) ,A61P 15/00 (2006.01) ,A61P 3/04 (2006.01) ,A61P 5/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
64
Cyclic peptides containing only normal peptide links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
06
using protecting groups or activating agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
04
on carriers
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12
Cyclic peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15
Drugs for genital or sexual disorders; Contraceptives
10
for impotence
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15
Drugs for genital or sexual disorders; Contraceptives
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
04
Anorexiants; Antiobesity agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
5
Drugs for disorders of the endocrine system
Applicants:
张嘎 ZHANG, Ga [CN/CN]; CN
Inventors:
张嘎 ZHANG, Ga; CN
Agent:
郑州联科专利事务所(普通合伙) ZHENGZHOU LIANKE PATENT AGENCY(COMMON PARTNERSHIP); 中国河南省郑州 金水区红专路58号 No.58,Hongzhuan Road, Jinshui Zhengzhou, Henan 450002, CN
Priority Data:
201210050125.601.03.2012CN
201210218017.528.06.2012CN
Title (EN) MELANOCYTE-STIMULATING HORMONE ANALOGUE FORMED BY CONNECTING CIRCULAR CORE SEQUENCE AND BIOTIN OR MEMBRANE-PENETRATING PEPTIDE
(FR) ANALOGUE DE LA MÉLANOSTIMULINE FORMÉ EN LIANT UNE SÉQUENCE NOYAU CIRCULAIRE À LA BIOTINE OU À UN PEPTIDE DE PÉNÉTRATION MEMBRANAIRE
(ZH) 环状核心序列与生物素或穿膜肽相连而成的促黑激素类似物
Abstract:
(EN) Provided are a melanocyte-stimulating hormone analogue formed by connecting a circular core sequence and biotin or membrane-penetrating peptide, and the preparation method and use thereof, wherein the melanocyte-stimulating hormone analogue is formed by connecting the functional unit and biotin or membrane-penetrating peptide, and the structure of the functional unit is Arg-c(Asp-Dab-D-Phe-Arg-Trp-Lys), and the structure of the membrane-penetrating peptide is Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg or Arg-Arg-Arg. The melanocyte-stimulating hormone analogue can be absorbed by permeating the mucosa or skin for treatment of male and female sexual dysfunction, obesity and hypo-pigmentation.
(FR) Cette invention concerne un analogue de la mélanostimuline formé en liant une séquence noyau circulaire à la biotine ou à un peptide de pénétration membranaire, son procédé de préparation et son utilisation, l'analogue de la mélanostimuline étant obtenu en liant l'unité fonctionnelle et la biotine ou le peptide de pénétration membranaire, la structure de l'unité fonctionnelle étant Arg-c(Asp-Dab-D-Phe-Arg-Trp-Lys), et la structure du peptide de pénétration membranaire étant Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg ou Arg-Arg-Arg. L'analogue de la mélanostimuline peut être absorbé à travers la muqueuse ou la peau dans le traitement des troubles sexuels de l'homme et de la femme, de l'obésité et de l'hypopigmentation.
(ZH) 提供了环状核心序列与生物素或穿膜肽相连而成的促黑激素类似物及其制备方法和应用,所述促黑激素类似物由功能单位与生物素或穿膜肽相连而成,功能单位结构为Arg-c(Asp-Dab-D-Phe-Arg-Trp-Lys),穿膜肽结构为Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg或者Arg-Arg-Arg。该促黑激素类似物可透过粘膜或皮肤吸入,用于男女性功能障碍、肥胖症、色素沉着不足症的治疗。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)