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1. (WO2013126690) MODIFIED MICROBIAL TOXIN RECEPTOR FOR DELIVERING AGENTS INTO CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/126690    International Application No.:    PCT/US2013/027307
Publication Date: 29.08.2013 International Filing Date: 22.02.2013
IPC:
C07K 19/00 (2006.01), C07K 14/705 (2006.01), A61K 47/42 (2006.01)
Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US/US]; 17 Quincy Street Cambridge, Massachusetts 02138 (US)
Inventors: MECHALY, Adva; (IL).
MCCLUSKEY, Andrew J.; (US).
COLLIER, R. John; (US)
Agent: RESNICK, David S.; Nixon Peabody LLP 100 Summer Street Boston, Massachusetts 02110 (US)
Priority Data:
61/602,218 23.02.2012 US
Title (EN) MODIFIED MICROBIAL TOXIN RECEPTOR FOR DELIVERING AGENTS INTO CELLS
(FR) RÉCEPTEUR DE TOXINE MICROBIENNE MODIFIÉE POUR ADMINISTRATION D'AGENTS DANS DES CELLULES
Abstract: front page image
(EN)We described a novel system of targeted cell therapy with a protein toxin, such as anthrax toxin, that has been modified to re-direct it to a desired cell target instead of its natural cell target. The system can be used for, e.g., targeted killing of undesired cells in a population of cells, such as cancer or overly active immune system cells.
(FR)L'invention concerne un nouveau système de thérapie cellulaire, ciblée comprenant une protéine toxine, telle que la toxine de l'anthrax, qui a été modifiée pour la rediriger vers la cible cellulaire souhaitée à la place de sa cible cellulaire naturelle. Le système peut être utilisé pour, par exemple, tuer de façon ciblée des cellules indésirables dans une population de cellules, telle que des cellules cancéreuses ou des cellules suractivées du système immunitaire.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)