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1. (WO2013126674) IDENTIFICATION OF ANTITUMOR COMPOUNDS USING PLACENTA
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/126674 International Application No.: PCT/US2013/027288
Publication Date: 29.08.2013 International Filing Date: 22.02.2013
IPC:
A01N 1/02 (2006.01)
Applicants: ANTHROGENESIS CORPORATION[US/US]; 33 Technology Drive Warren, NJ 07059, US
Inventors: HARIRI, Robert, J.; US
BHATIA, Mohit, B.; US
YE, Qian; US
Agent: INSOGNA, Anthony, M.; Jones Day 222 East 41st Street New York, NY 10017-6702, US
Priority Data:
61/602,52423.02.2012US
Title (EN) IDENTIFICATION OF ANTITUMOR COMPOUNDS USING PLACENTA
(FR) IDENTIFICATION DE COMPOSÉS ANTITUMORAUX À PARTIR DE PLACENTA
Abstract: front page image
(EN) Provided herein are methods of evaluating potential antitumor compounds, and thereby identifying antitumor compounds, using placenta or a portion thereof and tumor cells, and compositions for accomplishing the same. In one embodiment, provided herein is a method of determining whether a potential antitumor compound is effective against a plurality of tumor cells, comprising introducing a plurality of tumor cells to, e.g., into or onto, a mammalian placenta or portion thereof; contacting said plurality of tumor cells for a period of time with said antitumor compound; and determining whether said antitumor compound is effective against said tumor cells, wherein said antitumor compound is effective against said tumor cells if said antitumor compound over said period of time reduces the number of said tumor cells or reduces the growth rate of said tumor cells.
(FR) La présente invention concerne des méthodes d'évaluation de composés antitumoraux potentiels, et par conséquent d'identification de composés antitumoraux, à partir de placenta ou d'une portion de celui-ci et de cellules tumorales, et des compositions pour les accomplir. Un mode de réalisation concerne une méthode pour déterminer si un composé antitumoral potentiel est efficace contre une pluralité de cellules tumorales, comprenant l'introduction d'une pluralité de cellules tumorales, par exemple, dans ou sur, un placenta ou une portion de celui-ci de mammifère; la mise en contact de ladite pluralité de cellules tumorales pendant une période de temps avec ledit composé antitumoral; et la détermination de si ledit composé antitumoral est efficace contre lesdites cellules antitumorales, ledit composé antitumoral étant efficace contre lesdites cellules antitumorales si ledit composé antitumoral sur ladite période de temps réduit le nombre desdites cellules tumorales ou réduit le taux de croissance desdites cellules tumorales.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)