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1. (WO2013126617) BOUVARDIN DERIVATIVES AND THERAPEUTIC USES THEREOF

Pub. No.:    WO/2013/126617    International Application No.:    PCT/US2013/027200
Publication Date: Fri Aug 30 01:59:59 CEST 2013 International Filing Date: Fri Feb 22 00:59:59 CET 2013
IPC: A61K 31/165
Applicants: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
SUVICA, INC.
SU, Tin, Tin
GLADSTONE, Mara, N.
ZHANG, Gan
SAMMAKIA, Tarek
Inventors: SU, Tin, Tin
GLADSTONE, Mara, N.
ZHANG, Gan
SAMMAKIA, Tarek
Title: BOUVARDIN DERIVATIVES AND THERAPEUTIC USES THEREOF
Abstract:
The present invention is directed at bouvardin analogs arid related compounds for the treatment of disorders including cancer. Provided herein are bouvardin analogs and related compounds, pharmaceutical compositions and kits comprising at least one bouvardin analog or related compound, and methods for treating disorders including cancer. In some aspects the compounds inhibit translation elongation at the ribosome. The compounds are used in combination with radiation therapy or with known chemotherapeutic compositions.