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1. (WO2013126590) PHARMACEUTICAL COMPOSITION COMPRISING CD34+ CELLS

Pub. No.:    WO/2013/126590    International Application No.:    PCT/US2013/027163
Publication Date: Fri Aug 30 01:59:59 CEST 2013 International Filing Date: Fri Feb 22 00:59:59 CET 2013
IPC: A61K 35/14
A61K 47/00
C12N 5/071
A61P 9/10
A61K 35/12
Applicants: BAXTER INTERNATIONAL INC.
BAXTER HEALTHCARE S.A.
Inventors: MOTLAGH, Delara
COHEN, Amy
PALMER, Lora
AMRANI, David L.
Title: PHARMACEUTICAL COMPOSITION COMPRISING CD34+ CELLS
Abstract:
The invention relates to the field of treatment of ischemic conditions and diseases using a cell population comprising CD34+ cells isolated from peripheral blood of a subject. The invention provides a pharmaceutical composition comprising (i) a cell population comprising CD34+ cells, (ii) a plasma protein, and (iii) an isotonic solution comprising at least one salt, said isotonic solution comprising acetate, gluconate, or both acetate and gluconate. Methods of treating tissue damaged by ischemia in a subject and methods of treating a medical condition, wherein the pharmaceutical composition of the invention is administered, are further provided herein. Also, methods of promoting mobilization of CD34+ cells from bone marrow into peripheral blood are provided herein.