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1. (WO2013126521) COMPOSITIONS AND METHODS FOR TREATING NEUROGENIC DISORDERS OF THE PELVIC FLOOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/126521    International Application No.:    PCT/US2013/027058
Publication Date: 29.08.2013 International Filing Date: 21.02.2013
IPC:
A61P 21/00 (2006.01)
Applicants: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY [US/US]; 1705 El Camino Real Palo Alto, California 94306-1106 (US).
CIRCUIT THERAPEUTICS, INC. [US/US]; 1430 O'Brien Drive Menlo Park, California 94025 (US)
Inventors: DEISSEROTH, Karl A.; (US).
ADEN, Elizabeth R.; (US).
GRADINARU, Viviana; (US).
DELP, Scott L.; (US)
Agent: BORDEN, Paula A.; Bozicevic, Field & Francis LLP 1900 University Avenue, Suite 200 East Palo Alto, California 94303 (US)
Priority Data:
61/601,298 21.02.2012 US
Title (EN) COMPOSITIONS AND METHODS FOR TREATING NEUROGENIC DISORDERS OF THE PELVIC FLOOR
(FR) COMPOSITIONS ET MÉTHODES DESTINÉES À TRAITER LES TROUBLES NEUROGÈNES DU PLANCHER PELVIEN
Abstract: front page image
(EN)Provided herein are methods for the treatment of bladder dysfunction, including detrusor hyperreflexia and detrusor external sphincter dyssynergia, fecal incontinence, and/or sexual dysfunction in an individual via the use of stably expressed light-responsive opsin proteins capable of selective hyperpolarization or depolarization of the neural cells that innervate the muscles responsible for physiologic functioning of urinary bladder, external urinary sphincter, external anal sphincter, and the male and female genitalia.
(FR)Cette invention concerne des méthodes destinées à traiter les dysfonctionnements de la vessie, comprenant l'hyperréflexivité du détrusor et la dyssynergie détrusor-sphincter externe, l'incontinence fécale, et/ou les troubles sexuels chez un individu par utilisation de protéines d'opsine photoréactives exprimées de manière stable, qui sont capables d'hyperpolariser ou de dépolariser sélectivement les cellules neurales qui innervent les muscles responsables du fonctionnement physiologique de la vessie, du sphincter urinaire externe, du sphincter anal externe, et des organes génitaux mâles et femelles.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)