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1. (WO2013125622) DIPEPTIDYL PEPTIDASE-IV INHIBITOR
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/125622 International Application No.: PCT/JP2013/054290
Publication Date: 29.08.2013 International Filing Date: 21.02.2013
IPC:
A61K 38/00 (2006.01) ,A23L 1/30 (2006.01) ,A61P 3/10 (2006.01) ,A61P 9/00 (2006.01) ,A61P 43/00 (2006.01) ,C07K 5/08 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
23
FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
L
FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
1
Foods or foodstuffs; Their preparation or treatment
29
Modifying nutritive qualities of foods; Dietetic products
30
containing additives
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
08
for glucose homeostasis
10
for hyperglycaemia, e.g. antidiabetics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
08
Tripeptides
Applicants:
森永乳業株式会社 MORINAGA MILK INDUSTRY CO., LTD. [JP/JP]; 東京都港区芝五丁目33番1号 33-1, Shiba 5-chome, Minato-ku, Tokyo 1088384, JP
Inventors:
山田 明男 YAMADA Akio; JP
越智 大介 OCHI Daisuke; JP
桜井 琢磨 SAKURAI Takuma; JP
Agent:
渡邊 薫 WATANABE Kaoru; 東京都港区高輪2丁目20番29号サクセス泉岳寺ビル3階薫風国際特許事務所 KUNPU INTELLECTUAL PROPERTY AGENTS, SUCCESS-SENGAKUJI BLDG. 3F, 2-20-29, Takanawa, Minato-ku, Tokyo 1080074, JP
Priority Data:
2012-03579522.02.2012JP
Title (EN) DIPEPTIDYL PEPTIDASE-IV INHIBITOR
(FR) INHIBITEUR DE LA DIPEPTIDYL PEPTIDASE-IV
(JA) ジペプチジルペプチダーゼ-IV阻害剤
Abstract:
(EN) The purpose of the present invention is to provide an excellent dipeptidyl peptidase-IV inhibitor and others. A dipeptidyl peptidase-IV inhibitor, a hypoglycemic agent or an agent for preventing vascular endothelial dysfunction, each of which contains a peptide comprising Met-Lys-Pro as an active ingredient; and a method for preventing, ameliorating or treating a disease associated with dipeptidyl peptidase-IV, a disease associated with a hyperglycemic state, diabetes or a disease associated with vascular endothelial dysfunction or vascular dysfunction using a peptide comprising Met-Lys-Pro as an active ingredient. Preferably, the disease associated with dipeptidyl peptidase-IV is selected from hyperglycemia, diabetes, a diabetic complication, vascular endothelial dysfunction and vascular dysfunction.
(FR) Le but de la présente invention concerne un excellent inhibiteur de la dipeptidyl peptidase-IV et autres. Un inhibiteur de la dipeptidyl peptidase-IV, un agent hypoglycémique ou un agent pour prévenir le dysfonctionnement endothélial vasculaire, dont chacun contient un peptide comprenant Met-Lys-Pro en tant qu'ingrédient actif et un procédé permettant de prévenir, d'atténuer ou de traiter une maladie associée à la dipeptidyl peptidase-IV, une maladie associée à un état hyperglycémique, le diabète ou une maladie associée à un dysfonctionnement endothélial vasculaire ou un dysfonctionnement vasculaire à l'aide d'un peptide comprenant Met-Lys-Pro en tant qu'ingrédient actif. On choisira de préférence la maladie associée à la dipetidyl peptidase-IV parmi l'hyperglycémie, le diabète, une complication diabétique, un dysfonctionnement endothélial vasculaire et un dysfonctionnement vasculaire.
(JA)  優れたジペプチジルペプチダーゼ-IV阻害剤等を提供すること。 Met-Lys-Proからなるペプチドを有効成分として含有するジペプチジルペプチダーゼ-IV阻害剤、血糖低下剤又は血管内皮障害抑制剤;Met-Lys-Proからなるペプチドを有効成分として、ジペプチジルペプチダーゼ-IVに起因する疾患、高血糖状態に起因する疾患、糖尿病又は血管内皮障害若しくは血管障害に起因する疾患の、予防、改善又は治療方法。前記ジペプチジルペプチダーゼ-IVに起因する疾患が、高血糖症、糖尿病、糖尿病合併症、血管内皮障害及び血管障害から選ばれるものであるのが好適である。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)