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1. (WO2013125543) HETEROCYCLIC COMPOUND
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/125543    International Application No.:    PCT/JP2013/054054
Publication Date: 29.08.2013 International Filing Date: 19.02.2013
IPC:
C07D 471/04 (2006.01), A61K 31/437 (2006.01), A61K 31/444 (2006.01), A61K 31/496 (2006.01), A61K 31/497 (2006.01), A61K 31/506 (2006.01), A61P 1/04 (2006.01), A61P 17/00 (2006.01), A61P 17/06 (2006.01), A61P 19/02 (2006.01), A61P 25/00 (2006.01), A61P 29/00 (2006.01), A61P 37/02 (2006.01), A61P 37/06 (2006.01), A61P 43/00 (2006.01)
Applicants: TAKEDA PHARMACEUTICAL COMPANY LIMITED [JP/JP]; 1-1, Doshomachi 4-chome, Chuo-ku, Osaka-shi, Osaka 5410045 (JP)
Inventors: NAGAMIYA, Hiroyuki; (JP).
YOSHIDA, Masato; (JP).
SETO, Masaki; (JP).
MARUI, Shogo; (JP).
ODA, Tsuneo; (JP).
ISHICHI, Yuji; (JP).
SUZUKI, Hideo; (JP).
KUSUMOTO, Tomokazu; (JP).
YOGO, Takatoshi; (JP).
RHIM, Chul Yun; (KR).
YOON, Cheolhwan; (KR).
LEE, Gil Nam; (KR).
KANG, Hyun Bin; (KR).
KIM, Kwang Ok; (KR).
JEON, Hye Sun; (KR)
Agent: TAKASHIMA, Hajime; Meiji Yasuda Seimei Osaka Midosuji Bldg., 1-1, Fushimimachi 4-chome, Chuo-ku, Osaka-shi, Osaka 5410044 (JP)
Priority Data:
2012-034440 20.02.2012 JP
Title (EN) HETEROCYCLIC COMPOUND
(FR) COMPOSÉ HÉTÉROCYCLIQUE
(JA) 複素環化合物
Abstract: front page image
(EN)Provided is a prophylactic or therapeutic agent for autoimmune diseases (e.g., psoriasis, rheumatoid arthritis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus), which has an excellent Tyk2 inhibition activity. The present invention relates to a compound represented by formula (I) [wherein each symbol is as defined in the description attached] or a salt thereof.
(FR)L'invention concerne un agent prophylactique ou thérapeutique destiné à des maladies auto-immunes (par exemple le psoriasis, l'arthrite rhumatoïde, la maladie inflammatoire de l'intestin, le syndrome de Sjogren, la maladie de Behcet, la sclérose en plaques, le lupus érythémateux systémique), qui présente une excellente activité d'inhibition de Tyk2. La présente invention concerne un composé représenté à la formule (I) [dans laquelle chaque symbole est tel que défini dans la description ci-jointe] ou un sel de celui-ci.
(JA) 優れたTyk2阻害作用を有し、自己免疫疾患(例、乾癬、関節リウマチ、炎症性腸疾患、シェーグレン症候群、ベーチェット病、多発性硬化症、全身性エリテマトーデス等)等の予防または治療剤を提供する。 本発明は、式 (Ⅰ)[式中、各記号は添付の明細書中で定義した通りである。] で表される化合物またはその塩に関する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)