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1. (WO2013124229) HBV IMMUNOCOMPLEXES FOR RESPONSE PREDICTION AND THERAPY MONITORING OF CHRONIC HBV PATIENTS

Pub. No.:    WO/2013/124229    International Application No.:    PCT/EP2013/053150
Publication Date: Fri Aug 30 01:59:59 CEST 2013 International Filing Date: Tue Feb 19 00:59:59 CET 2013
IPC: G01N 33/576
G01N 33/68
Applicants: ROCHE DIAGNOSTICS GMBH
F. HOFFMANN-LA ROCHE AG
ACADEMIC MEDICAL CENTER AT THE UNIVERSITY OF AMSTERDAM
KLAUSE, Ursula
HIPP, Berthold
GRUNERT, Veit Peter
UPMEIER, Barbara
LOPATIN, Uri
DE NIET, Annikki
REESINK, Henk
ZAAIJER, Hans
Inventors: KLAUSE, Ursula
HIPP, Berthold
GRUNERT, Veit Peter
UPMEIER, Barbara
LOPATIN, Uri
DE NIET, Annikki
REESINK, Henk
ZAAIJER, Hans
Title: HBV IMMUNOCOMPLEXES FOR RESPONSE PREDICTION AND THERAPY MONITORING OF CHRONIC HBV PATIENTS
Abstract:
The present invention relates to a method for identifying a subject suffering from hepatitis B virus (HBV) infection as being susceptible to interferon treatment, said method comprising the steps of a) determining, in a sample of said subject, the amount of HBV immune complexes, b)comparing the amount of HBV immune complexes obtained in step a) to a reference value, and c) identifying a subject suffering from HBV infection as being susceptible to interferon treatment based on the result of the comparison made in step b). The present invention further relates to the use of the determination of the amount of HBV immune complexes in a sample from a subject suffering from HBV infection and of a detection agent for HBV immune complexes for identifying a subject suffering from HBV infection as being susceptible to interferon treatment. Furthermore, the present invention relates to a device and a kit allowing identifying a subject suffering from HBV infection as being susceptible to interferon treatment.