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1. (WO2013124072) IMMUNOASSAY FOR THE DETECTION OF C-TERMINAL FRAGMENTS OF AGRIN CONTAINING THE 22KDA C-TERMINAL FRAGMENT (CAF) OF AGRIN
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/124072 International Application No.: PCT/EP2013/000520
Publication Date: 29.08.2013 International Filing Date: 22.02.2013
IPC:
G01N 33/68 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants:
NEUROTUNE AG [CH/CH]; Wagistrasse 27a CH-8952 Schlieren, CH
Inventors:
HETTWER, Stefan; CH
VRIJBLOED, Jan, Willem; CH
DAHINDEN, Pius; CH
Agent:
EMMEL, Thomas; MEISSNER, BOLTE & PARTNER GBR Beselerstrasse 6 22607 Hamburg, DE
Priority Data:
12001255.425.02.2012EP
Title (EN) IMMUNOASSAY FOR THE DETECTION OF C-TERMINAL FRAGMENTS OF AGRIN CONTAINING THE 22KDA C-TERMINAL FRAGMENT (CAF) OF AGRIN
(FR) DOSAGE IMMUNOLOGIQUE POUR LA DÉTECTION DE FRAGMENTS C-TERMINAUX D'AGRINE CONTENANT LE FRAGMENT 22KDA C-TERMINAL (CAF) D'AGRINE
Abstract:
(EN) Immunoassay for the detection of CAF (22-Kd fragment of agrin) in C-terminal fragments of agrin in a sample, in which the CAF in the fragments to be detected can be present in one or both of the following 2 different conformations CAF-closed and CAF-open, wherein - in a first step the sample is incubated with a (primary) antibody with known binding properties to the different conformations of the CAF, with the antibody being capable to specifically bind to at least the CAF-open conformation, and - in a second step it is determined whether or not antibody-CAF-complexes have been formed after incubation.
(FR) La présente invention concerne un dosage immunologique pour la détection de CAF (fragment 22-Kd d'agrine) dans des fragments C-terminaux d'agrine dans un échantillon, le CAF dans les fragments à détecter pouvant être présent dans une des 2 configurations différentes suivantes ou les deux, CAF-fermé et CAF-ouvert. Le dosage se déroule de la manière suivante : dans une première étape, l'échantillon est incubé avec un anticorps (primaire) ayant des propriétés de liaison connues aux différentes configurations du CAF, l'anticorps étant capable de se lier spécifiquement à au moins la configuration CAF-ouvert, et dans une seconde étape, on détermine si les complexes anticorps-CAF ont été formés ou non après incubation.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)