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1. (WO2013124041) COMBINATION OF LIPID TRANSFER PROTEINS AND PLANT MATTER CONTAINING PHENOL DERIVATIVES WITH LOCAL MUCOSAL EFFICIENCY

Pub. No.:    WO/2013/124041    International Application No.:    PCT/EP2013/000410
Publication Date: Fri Aug 30 01:59:59 CEST 2013 International Filing Date: Wed Feb 13 00:59:59 CET 2013
IPC: A61K 31/00
A61K 31/05
Applicants: MERZ PHARMA GMBH & CO. KGAA
Inventors: BEUTLER, Rolf
SCHMIDT, Karlheinz
Title: COMBINATION OF LIPID TRANSFER PROTEINS AND PLANT MATTER CONTAINING PHENOL DERIVATIVES WITH LOCAL MUCOSAL EFFICIENCY
Abstract:
The present invention relates to combinations, particularly for local mucosal application, primarily in a solid, semi-solid or liquid preparation including lipid transfer proteins from plants, milk and plant matter (powder or extracts), such as ribwort, thyme, pelargonium, hairy rockrose and senega, containing one or more phenol derivatives. Such combinations, more particularly preparations thereof, have a primarily local mucosal effect due to an association formation (Mucobione). This results in a targeted modification of the physical properties, such as the surface tension, of aqueous systems (mucous layer). With the resulting change of the viscous-elastic properties, the mucous motility is improved and therefore the removal of undesired particles therefrom is facilitated. The Mucobione preparations are therefore suitable for physical use on neck, throat, nose, mouth and bronchial mucous membranes.