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Machine translation
1. (WO2013123996) NOVEL SIRNA INHIBITORS OF HUMAN ICAM-1
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/123996 International Application No.: PCT/EP2012/053149
Publication Date: 29.08.2013 International Filing Date: 24.02.2012
IPC:
C12N 15/113 (2010.01) ,A61K 31/712 (2006.01) ,A61P 35/00 (2006.01) ,A61P 11/00 (2006.01) ,A61P 29/00 (2006.01) ,A61P 9/10 (2006.01)
Applicants: WELLS, Ted[GB/GB]; GB (UsOnly)
HENDERSON, Duncan[GB/GB]; GB (UsOnly)
JACKSON, Clive[GB/GB]; GB (UsOnly)
GEBHARDT, Frank[DE/DE]; DE (UsOnly)
ASTRAZENECA UK LIMITED[GB/GB]; 2 Kingdom Street London Greater London W2 6BD, GB (AllExceptUS)
Inventors: WELLS, Ted; GB
HENDERSON, Duncan; GB
JACKSON, Clive; GB
GEBHARDT, Frank; DE
Agent: WINTER, Christopher; MedImmune Limited Milstein Building Granta Park Cambridge Cambridgeshire CB21 6GH, GB
Priority Data:
Title (EN) NOVEL SIRNA INHIBITORS OF HUMAN ICAM-1
(FR) NOUVEAUX INHIBITEURS D'ARNSI DE ICAM-1 HUMAIN
Abstract: front page image
(EN) An isolated si RNA comprising a sense sequence and an antisense sequence, wherein the sense and the antisense sequence are substantially complementary to each other to form a double-stranded structure that is 17-25 base pairs in length, and wherein the antisense sequence comprises a nucleotide sequence sufficiently complementary to a target human ICAM-1 nucleotide sequence selected from the group of sequences shown in Table 1.
(FR) L'invention concerne un ARN silencieux isolé comprenant une séquence sens et une séquence antisens, dans lequel les séquences sens et antisens sont pratiquement complémentaires l'une de l'autre pour former une structure double brin qui a 17-25 paires de bases de longueur, et dans lequel la séquence antisens comprend une séquence nucléotidique suffisamment complémentaire à une séquence nucléotidique de ICAM-1 cible humaine sélectionnée dans le groupe des séquences montrées dans le tableau 1.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)