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1. (WO2013123896) METHOD FOR PREPARING 3-O-BENZYL-1,2-O-ISOPROPYLIDENE-Α-L-FURAN IDOSE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/123896    International Application No.:    PCT/CN2013/071786
Publication Date: 29.08.2013 International Filing Date: 22.02.2013
IPC:
C07H 15/18 (2006.01), C07H 15/26 (2006.01), C07H 15/00 (2006.01), C07H 9/00 (2006.01), C07H 9/02 (2006.01), C07H 9/04 (2006.01), C07D 493/00 (2006.01), C07D 493/02 (2006.01), C07D 493/04 (2006.01)
Applicants: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. [CN/CN]; No.46 Waisha Road, Jiaojiang District Taizhou, Zhejiang 318000 (CN)
Inventors: GUO, Yanghui; (CN).
WEI, Hegeng; (CN).
ZHOU, Junhui; (CN).
WU, Yingqiu; (CN).
ZHANG, Yue; (CN).
BAI, Hua; (CN).
HE, Liang; (CN).
DING, Yili; (CN)
Agent: UNITALEN ATTORNEYS AT LAW; 7th Floor, Scitech Place No.22, Jian Guo Men Wai Ave., Chao Yang District Beijing 100004 (CN)
Priority Data:
201210050766.1 23.02.2012 CN
Title (EN) METHOD FOR PREPARING 3-O-BENZYL-1,2-O-ISOPROPYLIDENE-Α-L-FURAN IDOSE
(FR) PROCÉDÉ DE PRÉPARATION DE 3-O-BENZYL-1,2-O-ISOPROPYLIDÈNE-A-L-FURAN IDOSE
(ZH) 一种制备3-O-苄基-1,2-O-异亚丙基-α-L-呋喃艾杜糖的方法
Abstract: front page image
(EN)Provided is a method for preparing 3-O-benzyl-1,2-O-isopropylidene-α-L-furan idose, which comprises: (1) protecting hydroxyl of 3-O-benzyl-1,2-O-isopropylidene-α-D-glucofuranose (III) by benzoyl and methylsulfonyl to obtain 6-O-benzoyl-3-O-benzyl-1,2-O-isopropylidene-5-O-methylsulfonyl-α-D-glucofuranose (V); (2) subjecting the compound (V) to a cyclization reaction under an alkaline condition to obtain 5,6-epoxy-3-O-benzyl-1,2-O-isopropylidene-a-L-furan idose (VI); and (3) subjecting the compound (VI) to a ring-opening reaction to obtain 3-O-benzyl-1,2-O-isopropylidene-α-L-furan idose.
(FR)La présente invention concerne un procédé de préparation de 3-O-benzyl-1,2-O-isopropylidène-α-L-furan idose, ledit procédé comprenant : (1) la protection de l'hydroxyle du 3-O-benzyl-1,2-O-isopropylidène-α-D-glucofuranose (III) par benzoyle et méthylsulfonyle pour obtenir le 6-O-benzoyl-3-O-benzyl-1,2-O-isopropylidène-5-O-méthylsulfonyl-α-D-glucofuranose (V); (2) la sujétion du composé (V) à une réaction de cyclisation dans des conditions alcalines pour obtenir le 5,6-époxy-3-O-benzyl-1,2-O-isopropylidène-α-L-furan idose (VI); et (3) la sujétion du composé (VI) à une réaction d'ouverture de cycles pour obtenir le 3-O-benzyl-1,2-O-isopropylidène-α-L-furan idose.
(ZH)提供一种制备3-O-苄基-1,2-O-异亚丙基-α-L-呋喃艾杜糖的方法,包括:(1)3-O-苄基-1,2-O-异亚丙基-α-D-呋喃葡萄糖(III)经苯甲酰基和甲基磺酰基保护羟基后得到6-O-苯甲酰基-3-O-苄基-1,2-O-异亚丙基-5-O-甲基磺酰基—α-D-呋喃葡萄糖(V);(2)化合物(V)在碱性条件下进行环化反应得到5,6-环氧-3-O-苄基-1,2-O-异亚丙基-a-L-呋喃艾杜糖(VI);(3)化合物(VI)开环反应得到3-O-苄基-1,2-O-异亚丙基-α-L-呋喃艾杜糖。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)