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1. (WO2013123840) ANTITUMOR AZA-BENZO[F]AZULEN DERIVATIVE, METHOD FOR PREPARING SAME, AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/123840    International Application No.:    PCT/CN2013/070919
Publication Date: 29.08.2013 International Filing Date: 24.01.2013
IPC:
A61K 31/551 (2006.01), C07D 471/14 (2006.01), A61P 35/00 (2006.01)
Applicants: TIANYI BIOSCIENCE CO. LTD. [CN/CN]; 10 Xuefu Road,, Hi-Tech Zone Nanjing, Jiangsu 210061 (CN)
Inventors: WU, Xihan; (CN).
FU, Liwu; (CN).
ZHANG, Dongmei; (CN).
WANG, Yurong; (CN)
Agent: NANJING JINGWEI PATENT & TRADEMARK AGENCY CO.,LTD; 12th Fl.-B No.179 Zhongshan Road, Gulou, Nanjing, Jiangsu 210005 (CN)
Priority Data:
201210043316.X 24.02.2012 CN
Title (EN) ANTITUMOR AZA-BENZO[F]AZULEN DERIVATIVE, METHOD FOR PREPARING SAME, AND USE THEREOF
(FR) DÉRIVÉ AZA-BENZO [F] AZULÉN ANTITUMORAL, SON PROCÉDÉ DE PRÉPARATION, ET SON UTILISATION
(ZH) 抗肿瘤的氮杂苯并[f]薁衍生物其制备方法及其用途
Abstract: front page image
(EN)The present invention relates to the field of pharmaceutical chemistry, and particularly to an aza-benzo[f]azulen derivative (I) and an antitumor effect thereof. Pharmacological tests show that the compound of the present invention has in vitro and in vivo antitumor activities, and can be developed into clinical drugs for treating or controlling diseases such as stomach cancer, lung cancer, liver cancer, breast cancer, colon cancer, prostate cancer, and oral cancer.
(FR)La présente invention concerne le domaine de la chimie pharmaceutique, et en particulier à un dérivé (I) aza-benzo [f] azulén de classe-I et son effet antitumoral. Des tests pharmacologiques montrent que le composé de la présente invention a in vitro et in vivo des activités antitumorales, et peut être mis au point sous la forme de médicaments cliniques pour traiter ou contrôler des maladies comme le cancer de l'estomac, le cancer du poumon, le cancer du foie, le cancer du sein, le cancer du côlon, le cancer de la prostate, et le cancer de la bouche.
(ZH)本发明涉及药物化学领域,具体涉及一类氮杂苯并[f]薁衍生物(I)及其抗肿瘤作用,药理试验显示出本发明化合物具有体外和体内抗肿瘤活性,可用于发展成为治疗或控制胃癌、肺癌、肝癌,乳腺癌、结肠癌、前列腺癌,口腔癌等疾病的临床药物。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)