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1. (WO2013123791) BACILLUS, HYALURONIC ACID ENZYME, AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/123791    International Application No.:    PCT/CN2012/085503
Publication Date: 29.08.2013 International Filing Date: 29.11.2012
IPC:
C12N 1/20 (2006.01), C12N 9/26 (2006.01), C12N 15/56 (2006.01), C12P 19/28 (2006.01), C07K 14/32 (2006.01), A61K 8/73 (2006.01), A61K 31/728 (2006.01), A61P 17/02 (2006.01), A61P 9/00 (2006.01), A61Q 17/00 (2006.01), C12R 1/07 (2006.01)
Applicants: BLOOMAGE FREDA BIOPHARM CO., LTD. [CN/CN]; No.678 Tianchen Street, Hi-tech Development Zone Jinan, Shandong 250101 (CN)
Inventors: GUO, Xueping; (CN).
SHI, Yanli; (CN).
QIAO, Liping; (CN).
FENG, Ning; (CN).
WANG, Guanfeng; (CN).
LI, Haina; (CN).
XUE, Wei; (CN).
WANG, Haiying; (CN).
LUAN, Yihong; (CN).
LIU, Aihua; (CN)
Agent: CCPIT PATENT AND TRADEMARK LAW OFFICE; 8th Floor, Vantone New World Plaza 2 Fuchengmenwai Street, Xicheng District Beijing 100037 (CN)
Priority Data:
201210039111.4 21.02.2012 CN
201210108194.8 13.04.2012 CN
Title (EN) BACILLUS, HYALURONIC ACID ENZYME, AND USES THEREOF
(FR) BACILLE, HYALURONIDASE ET LEURS APPLICATIONS
(ZH) 一种芽孢杆菌、一种透明质酸酶、以及其用途
Abstract: front page image
(EN)Provided is a bacillus having the preservation number CGMCC 5744. The amino acid sequence of the hyaluronic acid enzyme produced by the bacillus is as represented in SEQ ID No:2. Also provided is a method for preparing a hyaluronic acid oligomer and salts thereof using the bacillus or using the hyaluronic acid enzyme produced by the bacillus, or a method for preparing a low molecular hyaluronic acid or salts thereof. The hyaluronic acid oligomer salts or the low molecular hyaluronic acid salts prepared have the advantages such as good transdermal absorption, high purity, no cytotoxicity, and strong oxidation resistance. Also provided are the uses of the bacillus having the preservation number CGMCC 5744, the hyaluronic acid enzyme, the hyaluronic acid oligomer or salts thereof, and the low molecular hyaluronic acid and salts thereof produced by the bacillus in the fields of cosmetics, food, and medicine.
(FR)L'invention concerne un bacille No.5744 CGMCC tenant lieu de numéro de préservation, une hyaluronidase obtenue à partir de ce bacille ainsi que sa séquence d'acides aminés SEQ ID NO:2. L'invention concerne aussi un procédé d'utilisation du bacille ou de la hyaluronidase obtenue à partir de ce bacille pour la production d'un acide hyaluronique oligomère ou ses sels, en variante, un procédé de préparation d'un acide hyaluronique à faible poids moléculaire ou ses sels. Ces sels d'acide hyaluronique oligomère ou ces sels d'acide hyaluronique à faible poids moléculaire ainsi obtenus sont remarquables en ce qu'ils font preuve, par exemple mais non limitativement, d'une bonne absorption percutanée, d'une pureté élevée, sont non toxiques et antioxydants. L'invention concerne en outre les applications dans les domaines de la cosmétique, de l'alimentation et de la médecine du bacille dont le numéro de préservation est CGMC No.5744, un one-iothalamate-dextran, l'acide hyaluronique oligomère et ses sels, l'acide hyaluronique à faible poids moléculaire et ses sels.
(ZH)提供了保藏编号为CGMCC No.5744的芽孢杆菌,由该芽孢杆菌生产的透明质酸酶,其氨基酸序列如SEQ ID NO:2所示。还提供了使用该芽孢杆菌或其生产的透明质酸酶制备寡聚透明质酸或其盐的方法,或者制备低分子透明质酸或其盐的方法。所制备的寡聚透明质酸盐或低分子透明质酸盐具有透皮吸收性好,纯度高,无细胞毒性,抗氧化能力强等优点。还提供了保藏编号为CGMCC No.5744的芽孢杆菌、由其生产的透明质酸酶、寡聚透明质酸或其盐、低分子透明质酸或其盐在化妆品、食品及医药领域中的用途。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)